Suction skin blister, skin window, and skin chamber techniques to determine extravascular passage of cefotaxime in humans
| Autor: | R F Frongillo, Galuppo L, A Moretti |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Adult
medicine.medical_specialty Materials science Suction Skin chamber Cefotaxime Adolescent Skin Window Technique Blister medicine Humans Pharmacology (medical) Aged Skin Pharmacology integumentary system Biological Transport Middle Aged Surgery Cephalosporins Infectious Diseases Skin blisters Biomedical engineering medicine.drug Research Article |
| Zdroj: | Antimicrobial agents and chemotherapy. 19(1) |
| ISSN: | 0066-4804 |
| Popis: | We report the results obtained in comparative study on the extravascular passage of cefotaxime, employing three different methods: suction skin blister, skin window, and skin chamber. Applying the skin blister method in two different ways, we also studied the influence that suction pressure and time lapse between blister formation and antibiotic injection had on the results obtained in order to standardize the method and establish repeatability of the results. Using the skin chamber method, we studied the influence that the different protein contents in the fluid used to fill the skin chamber had on extravascular concentrations. |
| Databáze: | OpenAIRE |
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