Normal Vascular Function as a Prerequisite for the Absence of Coronary Calcification in Patients Free of Cardiovascular Disease and Diabetes
| Autor: | Amir Lerman, Nicole P. Sandhu, Jing Li, Andreas J. Flammer, Randal J. Thomas, Paul A. Friedman, Martin Reriani, Lilach O. Lerman, Rebecca E. Nelson, Rajiv Gulati |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Endothelium Hyperemia Disease 030204 cardiovascular system & hematology Lower risk Asymptomatic 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine Diabetes Mellitus medicine Humans 030212 general & internal medicine cardiovascular diseases Endothelial dysfunction Vascular Calcification Aged Retrospective Studies business.industry nutritional and metabolic diseases Retrospective cohort study General Medicine Middle Aged medicine.disease Coronary Vessels 3. Good health Vasodilation medicine.anatomical_structure Cardiovascular Diseases Cardiology cardiovascular system Calcium Female Endothelium Vascular medicine.symptom Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business Artery |
| Zdroj: | Circulation journal : official journal of the Japanese Circulation Society |
| Popis: | Vascular calcification plays an important role in the development of atherosclerosis and that partially represents the burden of atherosclerotic plaque.1 The quantification of coronary artery calcium (CAC) can be performed using electron-beam computed tomography (EBCT) and because the presence of CAC gives important prognostic information for subsequent coronary events in individuals with or without cardiovascular disease (CVD),2,3 the technique has been included in current prevention guidelines.4 In recent years, there has been increasing interest in patients who are free from CAC (CAC score=0) on EBCT. Studies with long follow-up have demonstrated dramatically lower cardiovascular (CV) event rates in persons without any detectable CAC. The Multi-Ethnic Study of Atherosclerosis (MESA) showed an event rate of 0.6/1,000 person years among 3,409 patients with no CAC.5 In a cohort of 19,898 asymptomatic middle-age patients free from known coronary artery disease, a CAC score=0 was associated with |
| Databáze: | OpenAIRE |
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