Efficacy and Safety of a New Topical Testosterone Replacement Gel Therapy for the Treatment of Male Hypogonadism
| Autor: | Anders Neijber, Laurence Belkoff, Gerald B. Brock, Glenn R. Cunningham, Mitchell Efros, Masakazu Ando, Marc Gittelman, Dario Carrara, Jules T. Mitchel |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Hormone Replacement Therapy Endocrinology Diabetes and Metabolism 030232 urology & nephrology Urology Administration Cutaneous Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Clinical endpoint Humans Testosterone Young adult Adverse effect Aged 030219 obstetrics & reproductive medicine business.industry Male hypogonadism Hypogonadism Testosterone (patch) General Medicine Middle Aged Clinical trial Testosterone Gel Treatment Outcome Topical testosterone business Gels |
| Zdroj: | Endocrine Practice. 23:557-565 |
| ISSN: | 1530-891X |
| DOI: | 10.4158/ep161665.or |
| Popis: | Objective: Testosterone replacement therapy is indicated for male hypogonadism. This study aimed to evaluate the efficacy and safety of testosterone gel 2% (Tgel) over 90 days. Methods: This phase 3, open-label, noncomparator study was conducted in adult hypogonadal men (2 consecutive fasting serum testosterone values 86% subjects with symptoms consistent with testosterone deficiency). Subjects applied Tgel 23 mg/day (single pump-actuation using a hands-free cap applicator). The dose was uptitrated to 46 mg/day after 2 weeks if the 4-hour serum total testosterone level was |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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