Lutein delays photoreceptor degeneration in a mouse model of retinitis pigmentosa
| Autor: | Shi-Bo Tang, Xue-Song Mi, Ying Xu, Hui-Jun Zhang, Xiao-Bin Liu, Xiong-Min Chen, Qi-Hang Kong, Yu-Sang Liu, Kwok-Fai So, Jian-Su Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
endocrine system
genetic structures anti-inflammation glial fibrillary acidic protein lutein microglia pde6brd10 (rd10) mouse photoreceptor reactive gliosis retinal degeneration retinal disease retinitis pigmentosa food and beverages eye diseases Pde6brd10 (rd10) mouse Developmental Neuroscience sense organs Neurology. Diseases of the nervous system RC346-429 Research Article |
| Zdroj: | Neural Regeneration Research, Vol 17, Iss 7, Pp 1596-1603 (2022) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| Popis: | Retinitis pigmentosa is a retinal disease characterized by photoreceptor degeneration. There is currently no effective treatment for retinitis pigmentosa. Although a mixture of lutein and other antioxidant agents has shown promising effects in protecting the retina from degeneration, the role of lutein alone remains unclear. In this study, we administered intragastric lutein to Pde6brd10 model mice, which display degeneration of retinal photoreceptors, on postnatal days 17 (P17) to P25, when rod apoptosis reaches peak. Lutein at the optimal protective dose of 200 mg/kg promoted the survival of photoreceptors compared with vehicle control. Lutein increased rhodopsin expression in rod cells and opsin expression in cone cells, in line with an increased survival rate of photoreceptors. Functionally, lutein improved visual behavior, visual acuity, and retinal electroretinogram responses in Pde6brd10 mice. Mechanistically, lutein reduced the expression of glial fibrillary acidic protein in Müller glial cells. The results of this study confirm the ability of lutein to postpone photoreceptor degeneration by reducing reactive gliosis of Müller cells in the retina and exerting anti-inflammatory effects. This study was approved by the Laboratory Animal Ethics Committee of Jinan University (approval No. LACUC-20181217-02) on December 17, 2018. |
| Databáze: | OpenAIRE |
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