Injectable mesoporous bioactive nanoparticles regenerate bone tissue under osteoporosis conditions
| Autor: | Arcos, D., Gómez-Cerezo, N., Saiz-Pardo, M., de Pablo, D., Ortega, L., Enciso, S., Fernández-Tomé, B., Díaz-Güemes, I., Sánchez-Margallo, F.M., Casarrubios, L., Feito, M.J., Portolés, M.T., Vallet-Regí, M. |
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| Rok vydání: | 2022 |
| Předmět: |
Bioquímica
Bone Regeneration Tissue Scaffolds Interleukin-6 Tumor Necrosis Factor-alpha Biomedical Engineering Hydrogels General Medicine Biochemistry Bone and Bones Biomaterials Osteogenesis Química farmaceútica Animals Nanoparticles Osteoporosis Glass Rabbits Sistema musculoesquelético Hyaluronic Acid Molecular Biology Porosity Biotechnology |
| Zdroj: | E-Prints Complutense. Archivo Institucional de la UCM instname Acta Biomaterialia |
| ISSN: | 1878-7568 |
| Popis: | The osteogenic capability of mesoporous bioactive nanoparticles (MBNPs) in the SiO2–CaO system has been assessed in vivo using an osteoporotic rabbit model. MBNPs have been prepared using a double template method, resulting in spherical nanoparticles with a porous core-shell structure that has a high surface area and the ability to incorporate the anti-osteoporotic drug ipriflavone. In vitro expression of the pro-inflammatory genes NF-κB1, IL-6, TNF-α, P38 and NOS2 in RAW-264.7 macrophages, indicates that these nanoparticles do not show adverse inflammatory effects. An injectable system has been prepared by suspending MBNPs in a hyaluronic acid-based hydrogel, which has been injected intraosseously into cavitary bone defects in osteoporotic rabbits. The histological analyses evidenced that MBNPs promote bone regeneration with a moderate inflammatory response. The incorporation of ipriflavone into these nanoparticles resulted in a higher presence of osteoblasts and enhanced angiogenesis at the defect site, but without showing significant differences in terms of new bone formation. |
| Databáze: | OpenAIRE |
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