Dickkopf homolog 3 (DKK3 ): A candidate for detection and treatment of cancers?
| Autor: | Stephen L. Atkin, Michele Caraglia, Leila Hamzehzadeh, Amirhossein Sahebkar |
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| Přispěvatelé: | Hamzehzadeh, Leila, Caraglia, Michele, Atkin, Stephen L., Sahebkar, Amirhossein |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
cancer therapeutic Protein family Tumor suppressor gene Physiology Clinical Biochemistry Wnt pathway Biology 03 medical and health sciences 0302 clinical medicine Neoplasms microRNA Biomarkers Tumor Extracellular Animals Humans Promoter Regions Genetic Wnt Signaling Pathway Gene Adaptor Proteins Signal Transducing Cell Proliferation Polymorphism Genetic Oncogene Wnt signaling pathway Dickkopf-related protein 3 (DKK3) Genetic Therapy Cell Biology DNA Methylation Gene Expression Regulation Neoplastic Biomarker 030104 developmental biology 030220 oncology & carcinogenesis Cancer research biomarker Intercellular Signaling Peptides and Proteins Chemokines |
| Zdroj: | Journal of Cellular Physiology. 233:4595-4605 |
| ISSN: | 0021-9541 |
| Popis: | Wnt signaling is an evolutionary highly conserved pathway that is modulated by several inhibitors and activators, and plays a key role in numerous physiological processes. One of the extracellular Wnt inhibitors is the DKK (Dickkopf Homolog) family which has four members (Dkk1-4) and a unique Dkk3-related gene, Dkkl1 (soggy). DKK3 is a divergent member of the DKK protein family. Evidence suggests that DKK3 may serve as a potential therapeutic target in several types of human cancers. We review here the biological role of DKK3 as a tumor suppressor gene (TSG) or oncogene, and its correlation with various miRNAs. In addition, we discuss the role of polymorphisms and promoter methylation of the DKK3 gene, and of its expression in regulating cancer cell proliferation. Finally, we propose that DKK3 may be considered as both a biomarker and a therapeutic target in different cancers. |
| Databáze: | OpenAIRE |
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