Differences in Blood Pressure in Infants after General Anesthesia Compared to Awake Regional Anesthesia (GAS Study - A Prospective Randomized Trial)
| Autor: | B. S. von Ungern-Sternberg, A. Leo, Nicola Disma, David M. Polaner, Graham Bell, Davinia E. Withington, Geoff Frawley, N. S. Morton, Anthony Absalom, Andrew Davidson, Peter Szmuk, Sarah J Arnup, Rod W. Hunt, Mary Ellen McCann, Vanessa Young, David C. Bellinger, Francesca Izzo, Sulpicio G. Soriano, J. de Graaff |
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| Přispěvatelé: | Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Anesthesiology |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
BIRTH-WEIGHT INFANTS
medicine.medical_specialty Mean arterial pressure SURGERY FLOW Blood Pressure CHILDREN Anesthesia General Sevoflurane law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Anesthesia Conduction 030202 anesthesiology law 030225 pediatrics Anesthesiology Humans Medicine COHORT Prospective Studies Wakefulness BRAIN Prospective cohort study Bupivacaine Intention-to-treat analysis business.industry CHILDHOOD EXPOSURE Infant Newborn Infant SEVOFLURANE ANESTHESIA Surgery LIFE Blood pressure Anesthesiology and Pain Medicine Child Preschool Anesthesia ARM Hypotension business medicine.drug |
| Zdroj: | Anesthesia and Analgesia, 125(3), 837-845. LIPPINCOTT WILLIAMS & WILKINS Anesthesia & Analgesia, 125(3), 837-845. Lippincott Williams & Wilkins Anesthesia and Analgesia, 125(3), 837. Lippincott Williams and Wilkins |
| ISSN: | 0003-2999 |
| Popis: | BACKGROUND: The General Anesthesia compared to Spinal anesthesia (GAS) study is a prospective randomized, controlled, multisite, trial designed to assess the influence of general anesthesia (GA) on neurodevelopment at 5 years of age. A secondary aim obtained from the blood pressure data of the GAS trial is to compare rates of intraoperative hypotension after anesthesia and to identify risk factors for intraoperative hypotension.METHODS: A total of 722 infants ≤60 weeks postmenstrual age undergoing inguinal herniorrhaphy were randomized to either bupivacaine regional anesthesia (RA) or sevoflurane GA. Exclusion criteria included risk factors for adverse neurodevelopmental outcome and infants born at RESULTS: The relative risk of GA compared with RA predicting any measured hypotension of CONCLUSIONS: RA reduces the incidence of hypotension and the chance of intervention to treat it compared with sevoflurane anesthesia in young infants undergoing inguinal hernia repair. |
| Databáze: | OpenAIRE |
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