Galectin-3 in Peripheral Artery Disease. Relationships with Markers of Oxidative Stress and Inflammation
| Autor: | Jordi Camps, Anna Hernández-Aguilera, Jorge Joven, Anabel García-Heredia, Isabel Fort-Gallifa, Vicente Martín-Paredero, Noemí Cabré, Josep M. Simó, Fedra Luciano-Mateo |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Pathology Chemokine Galectin 3 Femoral artery 030204 cardiovascular system & hematology medicine.disease_cause F2-isoprostanes Pathogenesis lcsh:Chemistry 0302 clinical medicine Medicine oxidative stress Popliteal Artery lcsh:QH301-705.5 Spectroscopy biology General Medicine Middle Aged Computer Science Applications Femoral Artery medicine.anatomical_structure Galectin-3 Female medicine.symptom medicine.medical_specialty Inflammation peripheral artery disease Catalysis Article Inorganic Chemistry 03 medical and health sciences Peripheral Arterial Disease medicine.artery Adventitia galectin-3 otorhinolaryngologic diseases Humans Physical and Theoretical Chemistry Molecular Biology Aged business.industry Organic Chemistry Popliteal artery stomatognathic diseases 030104 developmental biology atherosclerosis lcsh:Biology (General) lcsh:QD1-999 Case-Control Studies biology.protein Endothelium Vascular business Oxidative stress Biomarkers |
| Zdroj: | International Journal of Molecular Sciences, Vol 18, Iss 5, p 973 (2017) International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 18; Issue 5; Pages: 973 |
| ISSN: | 1422-0067 |
| Popis: | Galectin-3 is a modulator of oxidative stress, inflammation, and fibrogenesis involved in the pathogenesis of vascular diseases. The present study sought to characterize, in patients with peripheral artery disease (PAD), the localization of galectin-3 in arterial tissue, and to analyze the relationships between the circulating levels of galectin-3 and oxidative stress and inflammation. It also sought to compare the diagnostic accuracy of galectin-3 with that of other biochemical markers of this disease. We analyzed femoral or popliteal arteries from 50 PAD patients, and four control arteries. Plasma from 86 patients was compared with that from 72 control subjects. We observed differences in the expression of galectin-3 in normal arteries, and arteries from patients with PAD, with a displacement of the expression from the adventitia to the media, and the intima. In addition, plasma galectin-3 concentration was increased in PAD patients, and correlated with serologic markers of oxidative stress (F2-isoprostanes), and inflammation [chemokine (C−C motif) ligand 2, C-reactive protein, β-2-microglobulin]. We conclude that the determination of galectin-3 has good diagnostic accuracy in the assessment of PAD and compares well with other analytical parameters currently in use. |
| Databáze: | OpenAIRE |
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