Portal venous velocity affects liver regeneration after right lobe living donor hepatectomy

Autor:	Li-Chueh Weng, Chia-Bang Chen, Ping-Yi Lin, Chia-Cheng Lin, Chih-Jan Ko, Su-Han Wang, Yao-Li Chen, Chen-Te Chou, Hui-Chuan Lin, Chen-Tai Hou, Ya-Lan Hsu, Chia-En Hsieh, Kuo-Hua Lin
Rok vydání:	2018
Předmět:	Adult Male medicine.medical_specialty Bilirubin medicine.medical_treatment Urology lcsh:Medicine 030230 surgery Liver transplantation Preoperative care 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Preoperative Care medicine Living Donors Hepatectomy Humans Prospective cohort study lcsh:Science Multidisciplinary business.industry Portal Vein Fatty liver lcsh:R medicine.disease Liver regeneration Lobe Liver Regeneration medicine.anatomical_structure Logistic Models chemistry Liver 030211 gastroenterology & hepatology lcsh:Q Female business Blood Flow Velocity
Zdroj:	PLoS ONE, Vol 13, Iss 9, p e0204163 (2018)
ISSN:	1932-6203
Popis:	Objectives We investigated whether chronological changes in portal flow and clinical factors play a role in the liver regeneration (LR) process after right donor-hepatectomy. Materials and methods Participants in this prospective study comprised 58 donors who underwent right donor-hepatectomy during the period February 2014 to February 2015 at a single medical institution. LR was estimated using two equations: remnant left liver (RLL) growth (%) and liver volumetric recovery (LVR) (%). Donors were classified into an excellent regeneration (ER) group or a moderate regeneration (MR) group based on how their LR on postoperative day 7 compared to the median value. Results Multivariate analysis revealed that low residual liver volume (OR = .569, 95% CI: .367– .882) and high portal venous velocity in the immediate postoperative period (OR = 1.220, 95% CI: 1.001–1.488) were significant predictors of LR using the RLL growth equation; high portal venous velocity in the immediate postoperative period (OR = 1.325, 95% CI: 1.081–1.622) was a significant predictor of LR using the LVR equation. Based on the two equations, long-term LR was significantly greater in the ER group than in the MR group (p < .001). Conclusion Portal venous velocity in the immediate postoperative period was an important factor in LR. The critical time for short-term LR is postoperative day 7; it is associated with long-term LR in donor-hepatectomy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529ce9477fbb4ccec7cacf0910128b45 https://pubmed.ncbi.nlm.nih.gov/30222781 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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