Nanoreactors: Strategies to encapsulate enzyme biocatalysts in virus-like particles
| Autor: | Bradley C. Bundy, Joshua W. Wilkerson, Seung-Ook Yang, Parker J. Funk, Steven K. Stanley |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Chemistry Virion Bioengineering Nanotechnology General Medicine Nanoreactor 010402 general chemistry Enzymes Immobilized 01 natural sciences Environmentally friendly 0104 chemical sciences Encapsulation (networking) 03 medical and health sciences 030104 developmental biology Enzyme Biocatalysis Process efficiency Molecular Biology Biotechnology |
| Zdroj: | New biotechnology. 44 |
| ISSN: | 1876-4347 |
| Popis: | Enzyme-mediated biocatalysis is generally more selective and environmentally friendly and requires less energy than chemocatalysis. However, factors such as temperature, acidity and the presence of proteases can negate enzyme activity. Encapsulation in virus-like particles is one promising method to mitigate these difficulties. Encapsulation also can be used to create multi-reaction nanoreactors that increase process efficiency by isolating reaction intermediates. To successfully encapsulate enzymes, a variety of methods involving both non-covalent and covalent interactions have been developed. Here we review promising virus-like particle encapsulation strategies, their advantages and remaining challenges. |
| Databáze: | OpenAIRE |
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