Early and late C‐peptide responses during oral glucose tolerance testing are oppositely predictive of type 1 diabetes in autoantibody‐positive individuals
| Autor: | Jay M. Sosenko, Mario A Cleves, Ingrid Libman, Dorothy J. Becker, Jerry P. Palmer, Heba M. Ismail, Maria J. Redondo, Kevan C. Herold, Mark A. Atkinson |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Gastroenterology Article Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Internal medicine Diabetes mellitus Internal Medicine medicine Humans Child Autoantibodies Type 1 diabetes C-Peptide Receiver operating characteristic C-peptide business.industry Proportional hazards model Area under the curve Autoantibody Glucose Tolerance Test medicine.disease Diabetes Mellitus Type 1 ROC Curve chemistry Child Preschool Female business Body mass index |
| Zdroj: | Diabetes Obes Metab |
| ISSN: | 1463-1326 1462-8902 |
| Popis: | We examined whether the timing of the C-peptide response during an oral glucose tolerance test (OGTT) in relatives of patients with type 1 diabetes (T1D) is predictive of disease onset. We examined baseline 2-h OGTTs from 670 relatives participating in the Diabetes Prevention Trial-Type 1 (age: 13.8 ± 9.6 years; body mass index z score: 0.3 ± 1.1; 56% male) using univariate regression models. T1D risk increased with lower early C-peptide responses (30–0 min) (χ(2) = 28.8, P < 0.001), and higher late C-peptide responses (120–60 min) (χ(2) = 23.3, P < 0.001). When both responses were included in a proportional hazards model, they remained independently and oppositely associated with T1D, with a stronger overall association for the combined model than either response alone (χ(2) = 41.1; P < 0.001). Using receiver operating characteristic curve analysis, the combined early and late C-peptide response was more accurately predictive of T1D than area under the curve C-peptide (P = 0.005). Our findings demonstrate that lower early and higher late C-peptide responses serve as indicators of increased T1D risk. |
| Databáze: | OpenAIRE |
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