Effects of SNPs (CYP1B1*2 G355T, CYP1B1*3 C4326G, and CYP2E1*5 G-1293C), Smoking, and Drinking on Susceptibility to Laryngeal Cancer among Han Chinese
| Autor: | Shiyu Liao, Jianhua Jin, Liyan Ni, Qiyu Bao, Faming Lin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Lifestyle Causes of Cancer
Male Risk medicine.medical_specialty Pathology Alcohol Drinking Genetic Causes of Cancer lcsh:Medicine Single-nucleotide polymorphism Lower risk Gastroenterology Polymorphism Single Nucleotide Asian People Risk Factors Internal medicine Genotype medicine Genetic predisposition Genetics Cancer Genetics Medicine and Health Sciences Humans Genetic Predisposition to Disease lcsh:Science Laryngeal Neoplasms Alleles Clinical Genetics Multidisciplinary business.industry Cancer Risk Factors lcsh:R Smoking Case-control study Cancer Biology and Life Sciences Human Genetics Cytochrome P-450 CYP2E1 Laryngeal Neoplasm Middle Aged medicine.disease Oncology Haplotypes Case-Control Studies Cohort Cytochrome P-450 CYP1B1 lcsh:Q Female business Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 9, Iss 10, p e106580 (2014) |
| ISSN: | 1932-6203 |
| Popis: | Purpose This study was conducted to explore the effects of genetic polymorphisms (CYP1B1*2 G355T, CYP1B1*3 C4326G, and CYP2E1*5 G-1293C) and environmental factors (smoking and drinking) on susceptibility to laryngeal cancer in a Han Chinese study group. Methods This case-control study included 552 Han Chinese patients diagnosed with laryngeal cancer and 666 healthy control subjects of the same ethnicity, similar age, and gender. Genetic polymorphisms were examined using multi-PCR and Matrix Assisted Laser Desorption Ionization - Time of Flight (MALDI-TOF MS) methodology. The association of these genetic and environmental factors with susceptibility to laryngeal cancer was evaluated using a statistical approach. Results The frequencies of all three polymorphisms in the patient cohort were significantly different from those in the control cohort. Compared to the control cohort, carriers of variant alleles of CYP1B1*2 355T and CYP2E1*5 -1293C showed a higher risk for developing laryngeal cancer (for CYP1B1*2 355T, adjusted OR = 2.657, P |
| Databáze: | OpenAIRE |
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