Anti-tumor effects of dendritic and tumor cell fusions are not dependent on expression of MHC class I and II by dendritic cells
| Autor: | Yuko Takagi, Michihito Niimura, Tetsuro Kikuchi, Tsuneya Ohno |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Cancer Research
Skin Neoplasms Genes MHC Class II Antigen presentation CD1 Genes MHC Class I chemical and pharmacologic phenomena Major histocompatibility complex Cancer Vaccines Mice HLA Antigens MHC class I Tumor Cells Cultured Animals Cytotoxic T cell Melanoma Mice Knockout Follicular dendritic cells biology Chemistry Dendritic Cells Neoplasms Experimental MHC restriction Mice Inbred C57BL Oncology Immunology Cancer research biology.protein Female Immunotherapy CD8 |
| Zdroj: | Cancer Letters. 213:49-55 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2004.04.010 |
| Popis: | Vaccination of fusion cells (FCs) made from dendritic and tumor cells elicits anti-tumor effects. We investigated whether major histocompatibility complex (MHC) class I and II play an important role in the induction of anti-tumor immunity by FCs. Immunization with fusion cells composed of syngeneic, allogeneic, or MHC I−/−II−/− DCs and B16 cells inhibited tumor growth. Elispot assay showed a higher population of interferon-γ secreting T lymphocytes in mice immunized with fusion cells. These data suggest that anti-tumor effects of DCs and tumor cell fusions are not dependent on the expression of MHC class I and II on DCs. |
| Databáze: | OpenAIRE |
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