Oral intake of γ-aminobutyric acid affects mood and activities of central nervous system during stressed condition induced by mental tasks
| Autor: | K. Takeshima, M. Motoki, Mujo Kim, Hidehiko Yokogoshi, N. Horie, K. Masuda, Ai Yoto, Sato Murao, Y. Yokoyama |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Clinical Biochemistry Central nervous system Administration Oral Electroencephalography Placebo Profile of mood states Biochemistry Aminobutyric acid Statistics Nonparametric Young Adult Internal medicine medicine Humans Single-Blind Method Problem Solving gamma-Aminobutyric Acid Cross-Over Studies medicine.diagnostic_test business.industry Organic Chemistry Brain Echoencephalography Crossover study Affect Alpha Rhythm Tranquilizing Agents Treatment Outcome Mood Endocrinology Blood pressure medicine.anatomical_structure Anesthesia Female Beta Rhythm business Stress Psychological |
| Zdroj: | Amino Acids. 43:1331-1337 |
| ISSN: | 1438-2199 0939-4451 |
| DOI: | 10.1007/s00726-011-1206-6 |
| Popis: | γ-Aminobutyric acid (GABA) is a kind of amino acid contained in green tea leaves and other foods. Several reports have shown that GABA might affect brain protein synthesis, improve many brain functions such as memory and study capability, lower the blood pressure of spontaneously hypertensive rats, and may also have a relaxation effect in humans. However, the evidence for its mood-improving function is still not sufficient. In this study, we investigated how the oral intake of GABA influences human adults psychologically and physiologically under a condition of mental stress. Sixty-three adults (28 males, 35 females) participated in a randomized, single blind, placebo-controlled, crossover-designed study over two experiment days. Capsules containing 100 mg of GABA or dextrin as a placebo were used as test samples. The results showed that EEG activities including alpha band and beta band brain waves decreased depending on the mental stress task loads, and the condition of 30 min after GABA intake diminished this decrease compared with the placebo condition. That is to say, GABA might have alleviated the stress induced by the mental tasks. This effect also corresponded with the results of the POMS scores. |
| Databáze: | OpenAIRE |
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