Monoclonal anti-EGFreceptor antibody (ior-R3) pharmacokinetic study in tumor bearing nude mice: Role of the receptor-mediated endocytosis on drug clearance
| Autor: | Jorge Duconge, J F Amador, A. Macías, J Matheu, I. Garcia, Irene Beausoleil, Rafael Fernández Castillo, E Fernández-Sánchez |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Mice Nude Monoclonal antibody Endocytosis Mice Pharmacokinetics Internal medicine Tumor Cells Cultured medicine Animals Humans Distribution (pharmacology) Pharmacology (medical) Pharmacology biology business.industry Antibodies Monoclonal Receptor-mediated endocytosis Immunotherapy Xenograft Model Antitumor Assays ErbB Receptors Endocrinology Monoclonal biology.protein Antibody business |
| Zdroj: | European Journal of Drug Metabolism and Pharmacokinetics. 27:101-105 |
| ISSN: | 2107-0180 0378-7966 |
| Popis: | With the purpose of describing the MAb ior-R3's kinetic behavior in disease state, this paper is focused on the study of this response using a human cancer (lung carcinoma cell line, H125) bearing nude mice animal model. This MAb was administered by a single 16 mg/Kg intravenous bolus dose and the blood samples were collected at several times ranging from 0 to 72 hours for serum drug quantification. The experimental data set was best fitted using a classical two-compartment mammilary pharmacokinetic (PK) model and the corresponding PK parameters were determined. Comparatively, the analysis of the more relevant physiologically-based PK parameters showed a significant enhancing of clearance as compound with the earlier reported study on healthy mice, increasing from 0.09 to 0.19 mL/h (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink