Differential influence of butyrate concentration on proximal and distal colonic mucosa in rats born germ-free and associated with a strain of Clostridium paraputrificum
| Autor: | Martine Bensaada, Françoise Popot, Jean-Claude Meslin, Claude Andrieux |
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| Přispěvatelé: | ProdInra, Migration, Unité de recherche d'Écologie et Physiologie du Système Digestif (UEPSD), Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Male
Mitotic index Physiology Colon Crypt Butyrate Biochemistry TUBE DIGESTIF In vivo medicine [SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular Biology Animals Germ-Free Life Large intestine [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Intestinal Mucosa Molecular Biology Clostridium biology Mucin biology.organism_classification Molecular biology digestive system diseases Epithelium Rats Inbred F344 Rats Butyrates medicine.anatomical_structure RAT Clostridium paraputrificum |
| Zdroj: | Comparative Biochemistry and Physiology-Part A: Molecular and Integrative Physiology Comparative Biochemistry and Physiology-Part A: Molecular and Integrative Physiology, Elsevier, 2001, 128A (2), pp.379-384 |
| ISSN: | 1095-6433 |
| Popis: | In vivo influence of butyrate in colonic mucosa was studied using a model of gnotobiotic rats monoassociated with a Clostridium paraputrificum. Rats were fed a diet containing increasing amounts of non-digestible carbohydrates, the fermentation of which led to modulated amounts of butyrate in the large intestine. In the proximal colon, the increase in the butyrate concentration alters crypt depth and the number of mucus-containing cells; the increase in butyrate was highly correlated with the number of neutral-mucin-containing cells. Conversely, in the distal colon, no relation was found between the increase in butyrate concentration and crypt depth or number of mucin-containing cells. In both the proximal and distal colon, the mitotic index remained unchanged. In conclusion, in vivo production of physiological quantities of butyrate had a trophic effect on proximal colonic mucosa, but did not influence the distal epithelium. |
| Databáze: | OpenAIRE |
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