Bronchopulmonary dysplasia in very preterm infants: Outcome up to preschool age, in a single center of Austria

Autor: Friedrich Reiterer, Ute Maurer-Fellbaum, Alexander Avian, Anna Scheuchenegger, Berndt Urlesberger, Bernhard Resch
Rok vydání: 2019
Předmět:
Male
Pediatrics
medicine.medical_specialty
Neonatal intensive care unit
growth
morbidity
030204 cardiovascular system & hematology
preterm infant
Cohort Studies
03 medical and health sciences
Child Development
0302 clinical medicine
Intensive Care Units
Neonatal
030225 pediatrics
bronchopulmonary dysplasia
mental disorders
Humans
Medicine
Respiratory Tract Infections
Retrospective Studies
neurodevelopment
business.industry
Incidence
Incidence (epidemiology)
Infant
Newborn
Infant
Gestational age
Retinopathy of prematurity
Original Articles
medicine.disease
Respiration
Artificial
Comorbidity
Bronchopulmonary dysplasia
Neurodevelopmental Disorders
Austria
Child
Preschool
Pediatrics
Perinatology and Child Health
Cohort
Female
Original Article
Neonatology
business
Infant
Premature
Follow-Up Studies
Cohort study
Zdroj: Pediatrics International
ISSN: 1442-200X
1328-8067
DOI: 10.1111/ped.13815
Popis: Background Bronchopulmonary dysplasia (BPD) is the most frequent chronic lung disease in infancy and is associated with neonatal comorbidity and impairment in pulmonary and neurodevelopmental (ND) long‐term outcome. Methods This was a retrospective, single‐center, cohort study to compare a cohort of very preterm infants (gestational age [GA], 24+0–28+6 weeks) with BPD (n = 44), with a cohort of GA‐matched preterm infants without BPD (n = 44) with regard to neonatal morbidity, incidence of lower respiratory tract infection (LRTI), ND outcome and growth to 2 years' corrected age (CA) and preschool age. Results Bronchopulmonary dysplasia (incidence, 11.3%) was associated with a higher rate of neonatal pneumonia (26% vs 7%, P = 0.001), longer total duration of mechanical ventilation (mean days, 21 vs 13, P < 0.001), and a higher rate of pulmonary hypertension (20.5% vs 0%, P = 0.002) and of severe retinopathy of prematurity (13.6% vs 0%, P = 0.026). Incidence of LRTI was significantly higher in the BPD infants (50% vs 26%, P = 0.025). ND outcome did not differ between the two groups. Growth at neonatal intensive care unit discharge was similar. In the BPD cohort, rate of weight < 10th percentile was higher at 2 years' CA (52% vs 30%, P = 0.041) and rate of head circumference < 10th percentile was higher at preschool age (59% vs 27%, P = 0.028). Conclusion Neonatal respiratory morbidity was significantly higher in the BPD cohort, but long‐term ND outcome did not differ. Infants with BPD had poorer growth.
Databáze: OpenAIRE
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