Limiting factors to oxygen transport on Mount Everest 30years after: a critique of Paolo Cerretelli's contribution to the study of altitude physiology

Autor: Guido Ferretti
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Physiology
Acclimatization
Mountaineering/physiology
Oxygen
Oxygen Consumption/ physiology
Orthopedics and Sports Medicine
Cardiac Output
Hypoxia
Altitude
VO2 max
Mitochondria/metabolism/physiology
Arteries
General Medicine
Limiting
Maximum oxygen consumption limitation
Mitochondria
Atmospheric Pressure
Capillaries/physiology/physiopathology
Muscle morphometry
Limiting factor
Cardiac Output/physiology
Acclimatization/ physiology
Anoxia/blood/physiopathology
Oxygen/blood/ metabolism
chemistry.chemical_element
Altitude adaptation
Humans
Lactate
Biology
Muscle blood flow
Cardiovascular Physiological Phenomena
Oxygen Consumption
Physiology (medical)
Lactic Acid
Muscle
Skeletal
Muscle
Skeletal/cytology/physiology/physiopathology
Pulmonary Gas Exchange
Lactic Acid/blood/metabolism
Public Health
Environmental and Occupational Health
Oxygen transport
Chronic hypoxia
ddc:616.8
Capillaries
Mountaineering
Arteries/metabolism
chemistry
Pulmonary Gas Exchange/physiology
human activities
Zdroj: European Journal of Applied Physiology, Vol. 90, No 3-4 (2003) pp. 344-350
ISSN: 1439-6319
Popis: In 1976, Paolo Cerretelli published an article entitled "Limiting factors to oxygen transport on Mount Everest” in the Journal of Applied Physiology . The paper demonstrated the role of cardiovascular oxygen transport in limiting maximal oxygen consumption (V̇O2max). In agreement with the predominant view of V̇O2max limitation at that time, however, its results were taken to mean that cardiovascular oxygen transport does not limit V̇O2max at altitude. So it was argued that the limiting factor could be in the periphery, and muscle blood flow was proposed as a possible candidate. Despite this suggestion, the conclusion generated a series of papers on muscle structural characteristics. These experiments demonstrated a loss of muscle oxidative capacity in chronic hypoxia, and thus provided an unambiguous refutation of the then widespread hypothesis that an increased muscle oxidative capacity is needed at altitude to compensate for the lack of oxygen. This analysis is followed by a short account of Cerretelli's more recent work, with a special attention to the subject of the so-called "lactate paradox”
Databáze: OpenAIRE
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