Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: Length optimization and zero carbon linker oximes

Autor:	Zhigang Chen, Yat Sun Or, Yonghua Gai, Datong Tang, Zhe Wang, Alexander Polemeropoulos
Rok vydání:	2008
Předmět:	Staphylococcus aureus Streptococcus pyogenes Stereochemistry Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests Zero carbon Biochemistry Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound Drug Resistance Bacterial Oximes Drug Discovery Binding site Molecular Biology Antibacterial agent Molecular Structure Bicyclic molecule Organic Chemistry Stereoisomerism Oxime Haemophilus influenzae Combinatorial chemistry Anti-Bacterial Agents Erythromycin Streptococcus pneumoniae Design synthesis chemistry Drug Design Molecular Medicine Methicillin Resistance Macrolides Linker
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 18:5078-5082
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2008.07.118
Popis:	We designed and synthesized a series of novel 3,6-bicyclolide oximes, possessing linkers of varying lengths to the secondary binding site. The E isomers exhibited excellent antibacterial profiles against a broad spectrum of resistant pathogens.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52923a0dbe11c44a0b0da894047d00ff https://doi.org/10.1016/j.bmcl.2008.07.118 Zobrazit plný text záznamu Full Text from ScienceDirect