ESTIMATING IN VITRO GLASS FIBER DISSOLUTION RATE FROM COMPOSITION
| Autor: | Walter Eastes, John G. Hadley, Russell M. Potter |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Inhalation Exposure
Linear function (calculus) Lung Neoplasms Materials science Borosilicate glass Health Toxicology and Mutagenesis Glass fiber Oxide Analytical chemistry Mineralogy Oxides In Vitro Techniques Toxicology Rats chemistry.chemical_compound Reaction rate constant Models Chemical Solubility chemistry Animals Glass Fiber Lung Mass fraction Dissolution |
| Zdroj: | Inhalation Toxicology. 12:269-280 |
| ISSN: | 1091-7691 0895-8378 |
| DOI: | 10.1080/089583700196149 |
| Popis: | A method is presented for calculating the dissolution rate constant of a borosilicate glass fiber in the lung, as measured in vitro, from the oxide composition in weight percent. It is based upon expressing the logarithm of the dissolution rate as a linear function of the composition. It was found that the calculated dissolution rate constant agreed with the measured value within the variation of the measured data in a set of compositions in which the dissolution rate constant ranged over a factor of 100. The method was shown to provide a reasonable estimate of dissolution over a considerably wider range of composition than what was used to determine the parameters, such as a set of data in which the dissolution rate constant varied over a factor of 100,000. The dissolution rate constant may be used to estimate whether disease would ensue following animal inhalation or intraperitoneal studies. |
| Databáze: | OpenAIRE |
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