Hexagonal boron nitride nanoparticles trigger oxidative stress by modulating thiol/disulfide homeostasis
| Autor: | Fatih Kar, Güngör Kanbak, Ceyhan Hacioglu, Hakan Senturk, Ozcan Erel, Ibrahim Sogut, Yapıncak Göncü, Nuran Ay, Almila Senat |
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| Přispěvatelé: | [Belirlenecek] |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Boron Compounds Health Toxicology and Mutagenesis Pharmacology toxicology Nanoparticle Assay Hexagonal boron nitride Toxicology medicine.disease_cause Thiol disulfide homeostasis Nanomaterials 03 medical and health sciences 0302 clinical medicine medicine Responses Animals Homeostasis Humans rat Disulfides Sulfhydryl Compounds Rats Wistar Boric-Acid Disulfide exchange Toxicity Chemistry Parkinsons-Disease General Medicine Combinatorial chemistry thiol-disulfide Disease Models Animal Oxidative Stress 030104 developmental biology Damage Parameters Nanoparticles Body Cell 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Humanexperimental toxicology. 40(9) |
| ISSN: | 1477-0903 |
| Popis: | Background: Hexagonal boron nitride nanoparticles (hBN NPs) are encouraging nanomaterials with unique chemical properties in medicine and biomedical fields. Until now, the optimal hBN NP's dosage and biochemical mechanism that can be used for in vivo systems has not been fully revealed. The main aim of this article is to reveal characteristics, serum and tissue interactions and any acute cytotoxic effect of different dose of hBN NPs for the first time. Methods: hBN NPs at concentrations varying between 50-3200 mu g/kg was administered by intravenous injection to Wistar albino rats (n = 80) divided into seven dosage and control groups. Blood and tissue samples were taken after 24 hours. Results: Our findings suggested that higher doses hBN NPs caused oxidative stress on the serum of rats dose-dependently. However, hBN NPs did not affect thiol/disulfide homeostasis on kidney, liver, spleen, pancreas and heart tissue of rats. Furthermore, hBN NPs increased serum disulfide formation by disrupting the thiol/disulfide balance in rats. Also, LOOH and MPO levels increased at high doses, while CAT levels decreased statistically. Conclusion: The results revealed that hBN NPs induce oxidative stress in a dose-dependent manner by modulating thiol/disulfide homeostasis in rats at higher concentrations Eskisehir Technical University Scientific Research Projects Commission [19ADP163] The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by Eskis comma ehir Technical University Scientific Research Projects Commission [Project No: 19ADP163]. WOS:000636510600001 2-s2.0-85103183585 PubMed: 33754873 |
| Databáze: | OpenAIRE |
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