Experimentally Induced Immunity to Chlamydial Abortion of Cattle
| Autor: | G. L. Crenshaw, D. G. McKercher, C. M. Mauris, J. H. Theis, E. M. Wada |
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| Rok vydání: | 1973 |
| Předmět: |
Injections
Intradermal Injections Subcutaneous Cattle Diseases Chlamydiae Chick Embryo Abortion Biology Immune system Pregnancy Immunity Methods medicine Animals Immunology and Allergy Epizootic Transmission (medicine) Vaccination Abortion Veterinary Chlamydia Infections biology.organism_classification medicine.disease Antibodies Bacterial Virology Infectious Diseases Bacterial Vaccines Immunology Cattle Female Intramuscular injection Vitelline Membrane |
| Zdroj: | Journal of Infectious Diseases. 128:231-234 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/128.2.231 |
| Popis: | Vaccination against bovine abortion caused by chlamydiae which, in earlier trials, failed to protect cattle against challenge by chlamydiae administered either by subcutaneous or intramuscular injection, protected against intradermal challenge. The implications of this latter finding are discussed in the light of the apparent epidemiologic pattern of the disease, particularly in regard to the possible nature of the immune response and the natural mode of transmission of the agent. Previous attempts to prevent epizootic bovine (chlamydial) abortion (EBA) by vaccination were unsuccessful [1, 2]. The route of challenge, by sc or im inoculation, was considered the most likely reason for failure. Unfortunately, because the occurrence of natural exposure was unpredictable and because of the lack of a specific serologic test to indicate when such exposure has taken place, field exposure could not be relied on as a means for evaluation of the efficacy of the vaccines tested. Although animals probably could be most effectively challenged by simulated natural exposure, the manner in which the agent |
| Databáze: | OpenAIRE |
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