Clinical characteristics and brain PET findings in 3 cases of dissociative amnesia : Disproportionate retrograde devicit and posterior middle temporal gyrus hypometabolism
| Autor: | F. Dubas, Eric Guedj, Catherine Thomas-Antérion, C. Jeanguillaume, Marielle Decousus |
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| Přispěvatelé: | Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Laboratoire Angevin de Recherche en Ingénierie des Systèmes (LARIS), Université d'Angers (UA) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Middle temporal gyrus Amnesia 050105 experimental psychology 03 medical and health sciences Young Adult [SPI]Engineering Sciences [physics] 0302 clinical medicine Visual memory Fluorodeoxyglucose F18 Physiology (medical) medicine Humans 0501 psychology and cognitive sciences Selective amnesia Autobiographical memory 05 social sciences Neuropsychology Dissociative Amnesia Retrograde amnesia General Medicine medicine.disease Temporal Lobe Neurology Positron-Emission Tomography Amnesia Retrograde Neurology (clinical) medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery Stress Psychological |
| Zdroj: | Clinical Neurophysiology Clinical Neurophysiology, Elsevier, 2014, 44 (4), pp.355-362. ⟨10.1016/j.neucli.2014.08.003⟩ |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.neucli.2014.08.003⟩ |
| Popis: | International audience; BackgroundPrecipitated bypsychological stress, dissociative amnesia occurs in the absence of identifiable brain damage. Its clinical characteristics and functional neural basis are still a matter of controversy.MethodsIn the present paper, we report 3 cases of retrograde autobiographical amnesia, characterized by an acute onset concomitant with emotional/neurological precipitants. We present 2 cases of dissociative amnesia with fugue (cases 1 and 2), and one case of focal dissociative amnesia after a minor head trauma (case 3). The individual case histories and neuropsychological characteristics are reported, as well as the whole-brain voxel-based 18FDG-PET metabolic findings obtained at group-level in comparison to 15 healthy subjects.ResultsAll patients suffered fromautobiographical memoryloss, in the absence of structural lesion. They had no significant impairment of anterograde memory or ofexecutive function. Impairment of autobiographical memory was complete for two of the three patients, with loss of personal identity (cases 1 and 2). A clinical recovery was found for the two patients in whom follow-up was available (cases 2 and 3). Voxel-based group analysis highlighted a metabolic impairment of the right posteriormiddle temporal gyrus. 18FDG-PET was repeated in case3, and showed a complete functional brain recovery.ConclusionThe situation of dissociative amnesia with disproportionateretrograde amnesiais clinically heterogeneous between individuals. Our findings may suggest that impairment of high-level integration of visual and/or emotional information processing involving dysfunction of the right posterior middle temporal gyrus could reduce triggering of multi-modalvisual memorytraces, thus impeding reactivation of aversive memories. |
| Databáze: | OpenAIRE |
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