Prevention of postcardiopulmonary bypass pericardial adhesions by a new resorbable collagen membrane
| Autor: | Julie Piquet, Massimo Ricci, Jean-Noël Fabiani, Patrick Bruneval, Christian Gagnieu, Philippe Menasché, Marie-Cécile Perier, Alain Bel |
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| Přispěvatelé: | Laboratoire de recherche en Hydrodynamique, Énergétique et Environnement Atmosphérique (LHEEA), École Centrale de Nantes (ECN)-Centre National de la Recherche Scientifique (CNRS), Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Descartes - Paris 5 (UPD5)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Pathology
Time Factors Adhesion (medicine) Tissue Adhesions Biocompatible Materials 030204 cardiovascular system & hematology law.invention tissue adhesion [SPI.MAT]Engineering Sciences [physics]/Materials 0302 clinical medicine law Fibrosis Models Materials Testing Pericardium Polytetrafluoroethylene Tissue Adhesion Cardiopulmonary Bypass biomaterial article collagen membrane pericardium adhesion Cardiac surgery Resorption medicine.anatomical_structure priority journal Models Animal Artificial repeat procedure Cardiology and Cardiovascular Medicine Pulmonary and Respiratory Medicine medicine.medical_specialty mesothelium cell Heart Diseases animal experiment tissue regeneration Collagen Type I Institutional Reports animal tissue 03 medical and health sciences Cardiopulmonary bypass medicine Animals Regeneration controlled study Wound Healing Membranes bioengineering nonhuman Sheep business.industry Animal Foreign-Body Reaction Membranes Artificial politef medicine.disease Sternotomy Surgery 030228 respiratory system inflammation epithelization Wound healing business |
| Zdroj: | Interactive Cardiovascular and Thoracic Surgery Interactive Cardiovascular and Thoracic Surgery, Oxford University Press (OUP), 2012, 14 (4), pp.469-473. ⟨10.1093/icvts/ivr159⟩ |
| ISSN: | 1569-9293 |
| DOI: | 10.1093/icvts/ivr159⟩ |
| Popis: | cited By 10; International audience; Reduction in mediastinal adhesions is an issue in cardiac surgery. To evaluate a porcine-bioengineered collagen membrane (Cova™ CARD) intended to promote tissue regeneration, 18 sheep underwent a sternotomy and a 30 min period of cardiopulmonary bypass. They were divided into three equal groups: pericardium left open, placement of an e-polytetrafluoroethylene membrane (Preclude®) taken as a non-absorbable substitute comparator and placement of the absorbable Cova™ CARD membrane. Four months thereafter, the study animals underwent repeat sternotomy and were macroscopically assessed for the degree of material resorption and the intensity of adhesions. Explanted hearts were evaluated blindly for the magnitude of the inflammatory response, fibrosis and epicardial re-mesothelialization. The bioengineered membrane was absorbed by 4 months and replaced by a loosely adherent tissue leading to the best adhesion score. There was no inflammatory reaction (except for a minimal one in an animal). Fibrosis was minimal (P = 0.041 vs Preclude®). The highest degree of epicardial re-mesothelialization, albeit limited, was achieved by the bioengineered group in which five of six sheep demonstrated a new lining of mesothelial cells in contrast to two animals in each of the other groups. This collagen membrane might thus represent an attractive pericardial substitute for preventing post-operative adhesions. © The Author 2012. |
| Databáze: | OpenAIRE |
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