A Review of Industry Funding in Randomized Controlled Trials Published in the Neurosurgical Literature—The Elephant in the Room
| Autor: | Paul Klimo, Nickalus R. Khan, Jock C Lillard, Douglas Kondziolka, Garrett T. Venable, L. Madison Michael, Nicholas B. Rossi, Vincent Nguyen, Chesney S Oravec, Brandy N Vaughn, Douglas R. Taylor, Hassan Saad, Fred G. Barker, Prayash Patel |
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| Rok vydání: | 2018 |
| Předmět: |
Research design
medicine.medical_specialty Drug Industry Neurosurgery MEDLINE Subspecialty Neurosurgical Procedures law.invention 03 medical and health sciences 0302 clinical medicine Bias Randomized controlled trial law Odds Ratio medicine Humans 030212 general & internal medicine Randomized Controlled Trials as Topic Conflict of Interest business.industry Conflict of interest Odds ratio Confidence interval Jadad scale Research Design Family medicine Surgery Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Neurosurgery. 83:890-897 |
| ISSN: | 1524-4040 0148-396X |
| Popis: | OBJECTIVE To analyze the role of industry sponsorship of randomized controlled trials (RCTs) published exclusively in 3 major North American neurosurgical journals. METHODS Our primary objective was to determine whether an association exists between study conclusion(s) in favor of industry sponsored drugs, devices/implants, or surgical techniques and industry sponsorship. The secondary objective was to describe the quality/quantity of these neurosurgical RCTs. RESULTS A total of 110 RCTs were analyzed, the majority were published in the Journal of Neurosurgery (85%) and were international in origin (55%). The most common subspecialty was spine (n = 29) and drug study was the most common type (n = 49). Overall quality was good with median Jadad and Detsky scores of 4 (range, 1-5) and 18 (range, 8-21), respectively. There was a statistically significant difference in RCTs with industry funding (31/40, 78%) versus those without (9/70, 13%) that published a favorable conclusion of the new drug, device/implant, or surgical technique (odds ratio [OR], 23.35; P < .0001). Multiple binomial logistic regression analysis identified "number of authors" as mildly protective (OR, 0.79; 95% confidence interval, 0.69-0.91; P = .001) and "industry funding" strongly predictive (OR, 12.34; 95% confidence interval, 2.97-51.29; P = .001) of a positive trial. CONCLUSION Industry funding was associated with a much greater chance of positive findings in RCTs published in neurosurgical journals. Further efforts are needed to define the relationship between the authors and financial sponsors of neurosurgical research and explore the reasons for this finding. |
| Databáze: | OpenAIRE |
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