Representation of Black patients in heart failure clinical trials
| Autor: | Tariq U. Azam, Monica M Colvin |
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| Rok vydání: | 2021 |
| Předmět: |
Change over time
Heart Failure medicine.medical_specialty education.field_of_study Future studies business.industry Population MEDLINE Disease 030204 cardiovascular system & hematology medicine.disease United States Representation (politics) Clinical trial Black or African American 03 medical and health sciences 0302 clinical medicine Heart failure Medicine Humans 030212 general & internal medicine Cardiology and Cardiovascular Medicine business Intensive care medicine education |
| Zdroj: | Current opinion in cardiology. 36(3) |
| ISSN: | 1531-7080 |
| Popis: | Purpose of review Black patients with heart failure in the United States are underrepresented in clinical trials relative to their overrepresentation in the heart failure population and in adverse heart failure outcomes. We aim to evaluate historical trends in this space and highlight recent developments. Recent findings Multiple landmark heart failure trials published since 2019 have underrepresented Black patients, though several discussed this lack of representation as limitations. A review of large heart failure clinical trials from 2001 to 2016 found persistent underrepresentation of Black patients without significant change over time. Trials enrolling from North America exclusively had more proportional representation, enrolling an average of 31.6% Black participants. Summary There is a shrinking proportion of Black patients in pivotal heart failure trials despite a higher prevalence of disease and associated adverse outcomes. There is increasing awareness of these disparities within the heart failure community, potentially leading to improved representation in future studies. |
| Databáze: | OpenAIRE |
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