T helper cell dysregulation with hepatitis B and rebalance with glucocorticoids
| Autor: | Juan-Juan Cui, Zhong-Hua Lu, Shou-gang Kuai, Zhao-Xia Ju, Li-Hua Huang, Wei Chen, Yi-Ling Zhu, Xiao-Ping Huang, He-Juan Du, Jianhe Gan, Wei Sun |
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| Rok vydání: | 2014 |
| Předmět: |
Time Factors
Regulatory T cell chemical and pharmacologic phenomena macromolecular substances Methylprednisolone Severity of Illness Index T-Lymphocytes Regulatory medicine T helper 17 cell Humans In patient Lymphocyte Count Glucocorticoids Evidence-Based Medicine business.industry fungi Gastroenterology food and beverages hemic and immune systems General Medicine T helper cell Hepatitis B medicine.disease medicine.anatomical_structure Treatment Outcome Case-Control Studies Immunology Th17 Cells business hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | World journal of gastroenterology. 20(48) |
| ISSN: | 2219-2840 |
| Popis: | To investigate T helper 17/regulatory T cell alterations in early severe hepatitis B and the effect of glucocorticoids.The study included 20 patients in the early stage of severe hepatitis B (SHB) and 11 healthy controls. All patients had elevated T helper 17 (Th17) levels, decreased regulatory T (Treg) cell levels, and significant Th17/Treg ratios.After glucocorticoid treatment, 16 patients showed improvement with significant decreases in Th17 levels, increases in Treg, and rebalanced Th17/Treg ratios. The four patients who showed no improvement had increases in both Th17 and Treg levels and an even higher Th17/Treg ratio than before.Glucocorticoid treatment can rectify Th17/Treg dysregulation in patients with SHB. |
| Databáze: | OpenAIRE |
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