Serum Lactate Levels in Infants Exposed Peripartum to Antiretroviral Agents to Prevent Mother-to-Child Transmission of HIV: Agence Nationale de Recherches Sur le SIDA et les Hépatites Virales 1209 Study, Abidjan, Ivory Coast
| Autor: | Besigin Towne-Gold, François Dabis, Renaud Becquet, Didier K. Ekouevi, Agence Nationale de Recherches Sur le Sida, Ida Viho, Stéphane Blanche, François Rouet, Charlotte Sakarovitch, Ramata Touré, Patricia Fassinou, Valériane Leroy |
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| Přispěvatelé: | Epidémiologie, santé publique et développement, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR99-ISPED, Ditrame Plus, Programme PAC-CI (ANRS 1201/1202), ANRS France Recherche Nord & sud Sida-hiv hépatites-CHU Treichville, Centre de recherche et de Diagnostic sur le Sida [Abidjan, Côte d'Ivoire] (CeDreS), Centre Hospitalier Universitaire de Treichville [Abidjan, Côte d'Ivoire] (CHU de Treichville), Service de pédiatrie, CHU Yopougon, Service d'immuno-hématologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), ANRS, SIDACTION, Becquet, Renaud, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR99-ISPED, Ditrame Plus, Programme PAC-CI ( ANRS 1201/1202 ), ANRS-CHU Treichville, Centre de recherche et de Diagnostic sur le Sida ( CeDreS ), CHU Treichville, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP] |
| Rok vydání: | 2006 |
| Předmět: |
Pediatrics
MESH : Prospective Studies MESH: Maternal-Fetal Exchange MESH : Pregnancy Trimester Third HIV Infections MESH: HIV-1 MESH: Pregnancy 0302 clinical medicine Pregnancy MESH : Female Prospective Studies 030212 general & internal medicine Sida Maternal-Fetal Exchange biology MESH: Infant Newborn Lamivudine MESH : Infant [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie MESH: HIV Infections MESH : Adult MESH: Infant Mitochondria 3. Good health Mitochondrial toxicity Anti-Retroviral Agents MESH: Pregnancy Trimester Third Female MESH : Mitochondria MESH : HIV-1 medicine.drug Adult medicine.medical_specialty Nevirapine MESH: Mitochondria Pregnancy Trimester Third MESH : Infant Newborn MESH: Anti-Retroviral Agents Article 03 medical and health sciences Zidovudine 030225 pediatrics MESH : HIV Infections medicine MESH : Anti-Retroviral Agents Humans Lactic Acid MESH: Humans Nucleoside analogue business.industry MESH : Humans Infant Newborn MESH : Maternal-Fetal Exchange Infant MESH: Adult MESH : Disease Transmission Vertical biology.organism_classification medicine.disease MESH: Prospective Studies Infectious Disease Transmission Vertical MESH : Pregnancy [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie MESH : Lactic Acid Pediatrics Perinatology and Child Health Immunology HIV-1 MESH: Lactic Acid [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie Hyperlactatemia business MESH: Female MESH: Disease Transmission Vertical |
| Zdroj: | Pediatrics Pediatrics, American Academy of Pediatrics, 2006, 118 (4), pp.e1071-7. ⟨10.1542/peds.2006-0371⟩ Pediatrics, American Academy of Pediatrics, 2006, 118 (4), pp.e1071-7. 〈10.1542/peds.2006-0371〉 |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.2006-0371 |
| Popis: | BACKGROUND. Mitochondrial toxicity was described in infants exposed to long-term antiretroviral regimens containing nucleoside analogues for the prevention of mother-to-child transmission of HIV. We measured the serum lactate levels in children born to HIV-1 infected African women receiving short-term antiretroviral prevention of mother-to-child transmission of HIV regimens. METHODS. A prospective study was conducted in women-child pairs from the third trimester of pregnancy to 3 months of life. The exposed group was formed by children exposed in utero to nucleoside analog antiretroviral regimens, zidovudine or zidovudine + lamivudine from 32 to 36 weeks of amenorrhea until delivery. All of these women received nevirapine single dose at the beginning of labor. The children received zidovudine during the first 7 days of life and a nevirapine single dose at day 3. The control group was formed by infants born to HIV-1-infected women who had received nevirapine single dose only and who were not exposed to nucleoside analog antiretroviral regimens. Serum lactate levels were measured at 4, 6, and 12 weeks of life by Cobas Integra 400. RESULTS. A total of 836 blood samples from 338 infants was collected (262 exposed and 76 controls). Median lactacidemia was 1.8 mmol/L (interquartile range: 1.2–2.7 mmol/L). Overall serum lactate levels ≥2.5 mmol/L, defining hyperlactatemia, were observed in 39 of the 292 infants who had ≥2 serum lactate measurements. The 3-month period prevalence of hyperlactatemia did not differ between the exposed group and the control group. All of the serum lactate levels returned to normal values in all of the subsequent samples. No case of symptomatic hyperlactatemia was detected during the study period. CONCLUSIONS. Increased lactate levels were identified equally in infants whose mother received short-term nucleoside analogs or nevirapine single dose for prevention of mother-to-child transmission of HIV. Although not rare, hyperlactatemia was not related to short-term exposure to nucleoside analog antiretroviral regimens. |
| Databáze: | OpenAIRE |
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