Increased ischemia-modified albumin and malondialdehyde levels in videothoracoscopic surgery
| Autor: | Aysel Kiyici, Mufide Oncel, Murat Oncel, GuvenSunam Sadi, Emel Sahin, Bahattin Adam |
|---|---|
| Přispěvatelé: | Selçuk Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
malondialdehyde medicine.medical_specialty Mean arterial pressure lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_treatment medicine.disease_cause 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine nitric oxide Medicine lcsh:RC705-779 business.industry Albumin Venous blood lcsh:Diseases of the respiratory system Malondialdehyde Surgery Ischemia modified albumin medicine.anatomical_structure Sympathectomy chemistry lcsh:RC666-701 030220 oncology & carcinogenesis Vascular resistance Original Article videothoracoscopic surgery Cardiology and Cardiovascular Medicine business Perfusion 030217 neurology & neurosurgery Oxidative stress |
| Zdroj: | Annals of Thoracic Medicine, Vol 11, Iss 1, Pp 66-70 (2016) Annals of Thoracic Medicine |
| ISSN: | 1998-3557 1817-1737 |
| Popis: | WOS: 000369748200007 PubMed: 26933460 BACKGROUND: Videothoracoscopic surgery leads to general organ hypoperfusion by reducing mean arterial pressure, systemic vascular resistance, and end-diastolic volume index. Oxidative stress occurs as a result of hypoperfusion. Evaluation of the short-term effects of videothoracoscopic sympathectomy on serum ischemia-modified albumin (IMA), malondialdehyde (MDA), and nitric oxide (NO) levels in patients with primary hyperhidrosis was aimed. METHODS: Twenty-six patients who underwent videothoracoscopic surgery were contributed in this study. Venous blood samples were obtained from these patients 1 h before and after the surgery. IMA, MDA, and NO levels were measured in serum samples by colorimetric methods. Albumin concentrations were also measured for each sample, and albumin-adjusted IMA levels were calculated. RESULTS: Postoperative IMA, albumin-adjusted IMA, and MDA values were significantly higher compared to the preoperative values (P = 0.003, 0.027, 0.018, respectively). However, postoperative NO levels were lower than the preoperative values (P = 0.002). There was no significant difference between pre- and postoperative albumin concentrations, and there was no significant correlation between the parameters tested. CONCLUSIONS: We can conclude that elevation in MDA and IMA levels after videothoracoscopic surgery was caused by increased oxidative stress due to minimal ischemia-reperfusion injury after the infusion of CO 2 during the surgical process. Videothoracoscopic sympathectomy operation causes a decrease in NO production, and this should be taken in consideration when evaluating nitrosative stress in videothoracoscopic surgery. |
| Databáze: | OpenAIRE |
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