Long non‐coding RNA UCA 1 contributes to the progression of oral squamous cell carcinoma by regulating the WNT /β‐catenin signaling pathway

Autor: Wei Zhang, Yufan Wang, Yong-Tao Yang, Shiyue Shen, Feng Wang, Hongyu Yang, Ju-Yi Lai, Jie Kong
Rok vydání: 2016
Předmět:
Male
0301 basic medicine
Cancer Research
Cell Survival
Carcinogenesis
Apoptosis
Biology
medicine.disease_cause
Metastasis
Mice
Cell growth
03 medical and health sciences
0302 clinical medicine
Cell Movement
Cell Line
Tumor
medicine
Animals
Humans
Gene silencing
Neoplasm Invasiveness
Gene Silencing
Neoplasm Metastasis
Wnt Signaling Pathway
beta Catenin
UCA1
Cell Proliferation
Wnt signaling pathway
Original Articles
General Medicine
cell invasion
medicine.disease
Xenograft Model Antitumor Assays
Long non-coding RNA
Tongue Neoplasms
Squamous carcinoma
Cell biology
oral squamous cell carcinoma
stomatognathic diseases
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Carcinoma
Squamous Cell
Disease Progression
RNA
Long Noncoding
Original Article
WNT/β‐catenin pathway
Signal transduction
Functional genomics
Zdroj: Cancer Science
ISSN: 1349-7006
1347-9032
Popis: With the development of the functional genomics studies, a mass of long non-coding RNAs (LncRNA) were discovered from the human genome. LncRNAs serve as pivotal regulator of genes, which are able to generate LncRNA-binding-protein complexes to modulate a great many of genes. Recently, the LncRNA urothelial carcinoma-associated 1 (UCA1) has been revealed to be dysregulated, which plays a critical role in the development of a few cancers. However, the role of biology and clinical signification of UCA1 in the tumorigenesis of oral squamous carcinoma (OSCC) remain unknown. Hereof, we found that UCA1 expression levels were upregulated aberrantly in TSCC tissues and associated with lymph node metastasis (LNM) and TNM stage. We explored the expression, function and molecular mechanism of LncRNA-UCA1 in the oral squamous cell carcinoma. In the present work, we demonstrated that UCA1 silencing suppressived the proliferation and metastasis, induced apoptosis of OSCC cell lines in vitro and in vivo, which might be related to the activation level of WNT/β-catenin signaling pathway. To sum up, our research results emphasize the pivotal role of UCA1 in the oncogenesis of OSCC and, revealed a novel LncRNA UCA1-β-catenin-WNT signaling pathway regulatory network, which may contribute to our understanding in the pathogenesis of OSCC and discover a viable LncRNA-directed diagnostic and therapeutic strategy for this fatal disease. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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