Perioperative statin therapy in cardiac and non-cardiac surgery: a systematic review and meta-analysis of randomized controlled trials
| Autor: | Juliano Pinheiro de Almeida, Ludhmila Abrahão Hajjar, Alessandro Putzu, Giovanni Landoni, Tiziano Cassina, Carolina Maria Pinto Domingues de Carvalho Silva, Alessandro Belletti |
|---|---|
| Přispěvatelé: | University of Zurich, Landoni, Giovanni, Putzu, A, de Carvalho, E Silva CMPD, de Almeida, Jp, Belletti, A, Cassina, T, Landoni, G, Hajjar, La. |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
610 Medicine & health ESTUDOS RANDOMIZADOS Review 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine 11171 Cardiocentro Ticino law.invention 03 medical and health sciences 0302 clinical medicine Non-cardiac surgery Randomized controlled trial law Internal medicine Anesthesiology Medicine Intensive care medicine 030212 general & internal medicine Myocardial infarction Mortality Stroke business.industry lcsh:Medical emergencies. Critical care. Intensive care. First aid Statins Statin Perioperative Odds ratio lcsh:RC86-88.9 Cardiac surgery medicine.disease Relative risk business 2706 Critical Care and Intensive Care Medicine |
| Zdroj: | Annals of Intensive Care Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Annals of Intensive Care, Vol 8, Iss 1, Pp 1-14 (2018) |
| ISSN: | 2110-5820 |
| Popis: | Background The effects of perioperative statin therapy on clinical outcome after cardiac or non-cardiac surgery are controversial. We aimed to assess the association between perioperative statin therapy and postoperative outcome. Methods Electronic databases were searched up to May 1, 2018, for randomized controlled trials of perioperative statin therapy versus placebo or no treatment in adult cardiac or non-cardiac surgery. Postoperative outcomes were: myocardial infarction, stroke, acute kidney injury (AKI), and mortality. We calculated risk ratio (RR) or odds ratio (OR) and 95% confidence interval (CI) using fixed-effects meta-analyses. We performed meta-regression and subgroup analyses to assess the possible influence of statin therapy regimen on clinical outcomes and trial sequential analysis to evaluate the risk of random errors and futility. Results We included data from 35 RCTs involving 8200 patients. Perioperative statin therapy was associated with lower incidence of postoperative myocardial infarction in non-cardiac surgery (OR = 0.44 [95% CI 0.30–0.64], p |
| Databáze: | OpenAIRE |
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