Endogenous Retinoids in the Pathogenesis of Alopecia Areata
| Autor: | Helen B. Everts, Kathleen A. Silva, David E. Ong, Charles J. Johnson, John P. Sundberg, Joseph L. Napoli, Jinshan Wang, Benjamin L. King, Kevin J. McElwee, David A. Whiting, Sonya P. Kamdar, Jin P. Szatkiewicz, Lloyd E. King, F. Jason Duncan |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Vitamin
medicine.medical_specialty Alopecia Areata Biopsy Retinoic acid Tissue Banks Dermatology Biology Chemokine CXCL9 Biochemistry Article Granzymes Pathogenesis Interferon-gamma Mice Retinoids 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Hair cycle Internal medicine medicine Animals Humans Vitamin A Chemokine CCL5 Molecular Biology 030304 developmental biology Autoimmune disease Mice Inbred C3H 0303 health sciences Interleukin-13 integumentary system Cell Biology Alopecia areata medicine.disease Hair follicle Animal Feed Rats Endocrinology medicine.anatomical_structure chemistry Disease Progression Hair Follicle |
| Zdroj: | The Journal of investigative dermatology |
| ISSN: | 0022-202X |
| DOI: | 10.1038/jid.2012.344 |
| Popis: | Alopecia areata (AA) is an autoimmune disease that attacks anagen hair follicles. Gene array in graft-induced C3H/HeJ mice revealed that genes involved in retinoic acid (RA) synthesis were increased, whereas RA degradation genes were decreased in AA compared with sham controls. This was confirmed by immunohistochemistry in biopsies from patients with AA and both mouse and rat AA models. RA levels were also increased in C3H/HeJ mice with AA. C3H/HeJ mice were fed a purified diet containing one of the four levels of dietary vitamin A or an unpurified diet 2 weeks before grafting and disease progression followed. High vitamin A accelerated AA, whereas mice that were not fed vitamin A had more severe disease by the end of the study. More hair follicles were in anagen in mice fed high vitamin A. Both the number and localization of granzyme B–positive cells were altered by vitamin A. IFNγ was also the lowest and IL13 highest in mice fed high vitamin A. Other cytokines were reduced and chemokines increased as the disease progressed, but no additional effects of vitamin A were seen. Combined, these results suggest that vitamin A regulates both the hair cycle and immune response to alter the progression of AA. |
| Databáze: | OpenAIRE |
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