Comparing the Cervista HPV HR Test and Hybrid Capture 2 Assay in a Dutch Screening Population: Improved Specificity of the Cervista HPV HR Test by Changing the Cut-Off

Autor: Geertruida H. de Bock, Lorian Slagter-Menkema, Jerome L. Belinson, Ed Schuuring, Bettien M. van Hemel, Harry G. Klip, Henk J. Buikema, Aniek Boers, Hilde Ghyssaert, G. Bea A. Wisman, Teus Ruitenbeek, Ate G.J. van der Zee
Přispěvatelé: Targeted Gynaecologic Oncology (TARGON), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Life Course Epidemiology (LCE)
Rok vydání: 2014
Předmět:
Oncology
lcsh:Medicine
Uterine Cervical Neoplasms
GUIDELINES
Cervical cancer screening
CYTOLOGY
Cancer screening
Medicine and Health Sciences
lcsh:Science
Early Detection of Cancer
HUMAN-PAPILLOMAVIRUS DNA
Netherlands
Cervical cancer
education.field_of_study
Multidisciplinary
Hybrid capture
WOMEN
Obstetrics and Gynecology
Middle Aged
Quality Improvement
Test (assessment)
Infectious Diseases
Female
Research Article
Adult
CERVICAL-CANCER
Human Papillomavirus Infection
medicine.medical_specialty
Urology
Concordance
Population
Sexually Transmitted Diseases
Sensitivity and Specificity
VALIDATION
Internal medicine
medicine
Humans
education
Gynecology
Genitourinary Infections
business.industry
lcsh:R
Papillomavirus Infections
External validation
HIGH-RISK HPV
Reproducibility of Results
PERFORMANCE
medicine.disease
PREVENTION
EXPERIENCE
Women's Health
lcsh:Q
business
Zdroj: PLoS ONE
PLoS ONE, 9(7):101930. PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 9, Iss 7, p e101930 (2014)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0101930
Popis: The diagnostic performance of the widely-used Cervista HPV HR test was compared to the Hybrid Capture 2 (HC2) test in a Dutch population-based cervical cancer screening program. In 900 scrapings of women with normal cytomorphology, specificity was 90% (95%CI: 87.84-91.87) for the Cervista HPV HR test and 96% (95%CI: 94.76-97.37) for the HC2 test with 93% agreement between both tests (κ = 0.5, p
Databáze: OpenAIRE
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