Usefulness of Extra Virgin Olive Oil Minor Polar Compounds in the Management of Chronic Kidney Disease Patients
| Autor: | Giulia Marrone, Annalisa Noce, Silvia Urciuoli, Nicola Di Daniele, Annalisa Romani, Manuela Di Lauro, Anna Pietroboni Zaitseva, Francesca Di Daniele |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Mediterranean diet antioxidant activity Mediterranean medicine.disease_cause Diet Mediterranean Gastroenterology Antioxidants Cyclopentane Monoterpenes chemistry.chemical_compound Settore MED/14 Surveys and Questionnaires Azotemia 80 and over Renal Insufficiency Chronic Aged 80 and over Nutrition and Dietetics medicine.diagnostic_test Middle Aged Phenylethyl Alcohol C-Reactive Protein Body Composition Female medicine.symptom lcsh:Nutrition. Foods and food supply hydroxytyrosol Glomerular Filtration Rate medicine.medical_specialty Renal function lcsh:TX341-641 Article extra virgin olive oil oleocanthal Phenols Internal medicine medicine Albuminuria Humans Renal Insufficiency Chronic Olive Oil polyphenols Aged Inflammation Aldehydes business.industry medicine.disease Diet Uric Acid Oxidative Stress chemistry Uric acid Lipid profile business Oxidative stress Biomarkers chronic kidney disease Food Science Kidney disease |
| Zdroj: | Nutrients Volume 13 Issue 2 Nutrients, Vol 13, Iss 581, p 581 (2021) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13020581 |
| Popis: | Chronic kidney disease (CKD) is one of the most common chronic non-communicable degenerative diseases and it represents an important risk factor for cardiovascular morbidity and mortality. The Mediterranean diet, in which extra virgin olive oil (EVOO) is the main source of vegetal fats, represents a nutritional-diet regimen that is useful for the treatment of CKD and its comorbidities. We tested two different EVOOs, characterized by a high (Synergy) and medium (Luxolio) content of minor polar compounds (MPCs), detected by HPLC-DAD-MS analysis, in 40 nephropathic patients, at a dose of 40 mL/day for 9 weeks. We evaluated the effects of these two EVOOs on renal function, body composition, oxidative stress, and inflammatory state, after 9 weeks of EVOOs consumption (T1) and after 2 months of wash-out (T2). We observed an improvement of renal function biomarkers (estimated-glomerular filtration rate, albuminuria, azotemia, uric acid), lipid profile, oxidative stress, inflammatory parameters (erythrocyte sedimentation rate, C-reactive protein) and in body composition at T1. These healthy effects were greater and persisted over time after the wash-out period in Synergy patients. The high MPC EVOO content seems to exert an antioxidant and anti-inflammatory effect in nephropathic patients and these protective actions are maintained over time. |
| Databáze: | OpenAIRE |
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