Is photodynamic therapy a relevant therapeutic option in refractory benign familial pemphigus (Hailey–Hailey disease)? A series of eight patients
| Autor: | Olivier Dereure, Maha Alsahli, Aurélie Du Thanh, Céline Girard, A. Debu, Didier Bessis, Bernard Guillot |
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| Přispěvatelé: | Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Pathogénèse et contrôle des infections chroniques (PCCI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Montpellier (CHU Montpellier )-Université de Montpellier (UM) |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Light Pemphigus Benign Familial medicine.medical_treatment education Pain Photodynamic therapy Dermatology Disease 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Refractory Quality of life Methyl aminolevulinate medicine Multiple treatments Humans Benign familial pemphigus Aged Photosensitizing Agents business.industry Drug Tolerance Middle Aged medicine.disease Levulinic Acids Hailey–Hailey disease 3. Good health Treatment Outcome Photochemotherapy methyl-aminolevulinate photodynamic therapy 030220 oncology & carcinogenesis Quality of Life Female business [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Dermatological Treatment Journal of Dermatological Treatment, Informa Healthcare, 2017, 28 (7), pp.678-682. ⟨10.1080/09546634.2017.1308461⟩ |
| ISSN: | 1471-1753 0954-6634 |
| DOI: | 10.1080/09546634.2017.1308461 |
| Popis: | Treatment of benign familial pemphigus or Hailey-Hailey disease (HHD), a rare inherited condition associated with a significant impairment of quality of life, is often challenging and disappointing with frequent relapses and infectious complications. Topical photodynamic therapy (PDT) may offer new perspectives in this difficult setting.Eight patients with long-lasting HHD lesions refractory to multiple treatments were treated on at least one involved site with PDT using methyl-amino levulinate with a standardized protocol of three sessions of irradiation separated by 3-week intervals.A complete or partial clearing was achieved in all treated areas, and the result was satisfactorily maintained in all cases after a follow-up period ranging from 3 to 36 months. Results were of higher quality in non-inguinal areas. Tolerance was overall acceptable with local pain during and shortly after irradiation being the main limiting factor.Our series, although limited in size, emphasizes the interest of PDT in this difficult condition even though results may be incomplete. Treatment-related pain can be adequately managed by prior analgesics, cooling with sprayed water and local tumescent anesthesia. Overall, PDT appears as a relevant option in refractory HHD management with a favorable benefit/risk ratio. |
| Databáze: | OpenAIRE |
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