A long surviving case of amyotrophic lateral sclerosis with atrophy of the frontal lobe: a comparison with the Mitsuyama type
| Autor: | Mitsuhiro Tsujihata, Takayoshi Ikeda, Masao Kishikawa, Shimokawa I, Iseki M, Nagasato K, Tatsufumi Nakamura |
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| Rok vydání: | 1995 |
| Předmět: |
Pathology
medicine.medical_specialty Central nervous system Pathology and Forensic Medicine Central nervous system disease Cellular and Molecular Neuroscience Atrophy Degenerative disease medicine Humans Amyotrophic lateral sclerosis Cerebral Cortex Cell Death business.industry Amyotrophic Lateral Sclerosis Middle Aged medicine.disease Spinal cord Frontal Lobe Surgery medicine.anatomical_structure Spinal Cord Frontal lobe Pseudobulbar signs Female Autopsy Neurology (clinical) business Brain Stem |
| Zdroj: | Acta Neuropathologica. 89:189-193 |
| ISSN: | 1432-0533 0001-6322 |
| Popis: | A female patient with amyotrophic lateral sclerosis (ALS) showing psychiatric symptoms during her last 2 years of life is reported. Although pseudobulbar signs were seen at the onset of ALS and no respirator was used, the period from onset to death was rather long (9 years). The spinal lesions showed features common to ordinary ALS, while the marked atrophy with destructive changes throughout the frontal lobe seemed to be considerably more severe than that seen with either ordinary ALS or the Mitsuyama type of ALS. Since the clinical manifestations and histological characteristics are apparently different from those of the Mitsuyama type, our case may be a new nosological variant of ALS with psychiatric manifestations. |
| Databáze: | OpenAIRE |
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