Biomedical Applications of polymeric micelles in the treatment of diabetes mellitus: Current success and future approaches

Autor: Jaskiran Kaur, Monica Gulati, Flavia Zacconi, Harish Dureja, Raimar Loebenberg, Md Salahuddin Ansari, Othman AlOmeir, Aftab Alam, Dinesh Kumar Chellappan, Gaurav Gupta, Niraj Kumar Jha, Terezinha de Jesus Andreoli Pinto, Andrew Morris, Yahya E. Choonara, Jon Adams, Kamal Dua, Sachin Kumar Singh
Rok vydání: 2022
Předmět:
Zdroj: Expert Opinion on Drug Delivery. 19:771-793
ISSN: 1744-7593
1742-5247
DOI: 10.1080/17425247.2022.2087629
Popis: INTRODUCTION: Diabetes mellitus (DM) is the most common metabolic disease and multifactorial, harming patients worldwide. Extensive research has been carried out in the search for novel drug delivery systems offering reliable control of glucose levels for diabetics, aiming at efficient management of DM. AREAS COVERED: Polymeric micelles (PMs) as smart drug delivery nanocarriers are discussed, focusing on oral drug delivery applications for the management of hyperglycaemia. The most recent approaches used for the preparation of smart PMs employ molecular features of amphiphilic block copolymers (ABCs), such as stimulus sensitivity, ligand conjugation, and as a more specific example the ability to inhibit islet amyloidosis. EXPERT OPINION: PMs provide a unique platform for self-regulated or spatiotemporal drug delivery, mimicking the working mode of pancreatic islets to maintain glucose homeostasis for prolonged periods. This unique characteristic is achieved by tailoring the functional chemistry of ABCs considering the physicochemical traits of PMs, including sensing capabilities, hydrophobicity etc. In addition, the application of ABCs for the inhibition of conformational changes in islet amyloid polypeptide garnered attention as one of the root causes of DM. However, research in this field is limited and further studies at the clinical level are required.
Databáze: OpenAIRE
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