Mechanisms involved in the chemoprotective effects of rosemary extract studied in human liver and bronchial cells
| Autor: | Ornella Avanti, Katherine Macé, Andrea M. A. Pfeifer, Elizabeth A. Offord |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Cancer Research
Aflatoxin B1 Antioxidant medicine.medical_treatment Blotting Western Bronchi Mutagen medicine.disease_cause Carnosol Mixed Function Oxygenases DNA Adducts chemistry.chemical_compound Cytochrome P-450 Enzyme System Cytochrome P-450 CYP1A2 medicine Cytochrome P-450 CYP3A Humans Spices Cells Cultured Glutathione Transferase chemistry.chemical_classification Plant Extracts Carnosic acid Glutathione Enzyme Liver Oncology chemistry Mechanism of action Biochemistry Chemoprotective medicine.symptom Mutagens |
| Zdroj: | Cancer Letters. 114:275-281 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/s0304-3835(97)04680-6 |
| Popis: | Natural polyphenols found in rosemary have not only potent antioxidant activities but also anticarcinogenic properties. We have studied some of the molecular mechanisms involved in their chemopreventive action using in vitro human liver and bronchial cell models. Rosemary extract, or its active components, carnosol or carnosic acid are potent inhibitors, of DNA adduct formation induced by benzo( a )pyrene or aflatoxin B 1 . At least two mechanisms are involved in the anticarcinogenic action of rosemary extract: (i) inhibition of the metabolic activation of procarcinogens catalysed by the phase I cytochrome P450 enzymes; (ii) induction of the detoxification pathway catalysed by the phase II enzymes such as glutathione S-transferase. |
| Databáze: | OpenAIRE |
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