Low plasma vitamin D as a predictor of uterine fibroids in a nigerian population
| Autor: | Abubakar A Panti, Aisha Nana Adamu, Jamila Abubakar Garba, Muhammad Bashir Abdulrahman, Mohammad Kaoje Ahmad, Constance E Shehu, KA Tunau |
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| Rok vydání: | 2021 |
| Předmět: |
Gynecology
Adult medicine.medical_specialty Leiomyoma business.industry Uterine fibroids Uterus Nigeria General Medicine Nigerian population Odds ratio Venous blood medicine.disease female genital diseases and pregnancy complications Confidence interval medicine.anatomical_structure Cross-Sectional Studies Statistical significance Uterine Neoplasms Vitamin D and neurology Medicine Humans Female Vitamin D business |
| Zdroj: | The Nigerian postgraduate medical journal. 28(3) |
| ISSN: | 1117-1936 |
| Popis: | Background Uterine fibroid is the most common benign tumour of the uterus and the exact cause is unknown. Vitamin D has been found to inhibit cell proliferation and enhance apoptosis in vitro. Aim The aim of this study is to compare the plasma level of Vitamin D among women with uterine fibroids and those without uterine fibroids. Materials and methods This was an analytical cross-sectional study conducted among women with uterine fibroids and those without uterine fibroids. An interviewer-administered questionnaire was used to obtain relevant information. Five millilitres of venous blood was obtained for plasma Vitamin D assay. Data analysis was performed using the SPSS version 22. Level of significance was set at P Results There were 100 participants recruited for the study. The mean age of the participants with uterine fibroid was 35.06 ± 6.6 years and that of controls was 33.28 ± 7 years. The mean plasma level of Vitamin D for all the participants was 12.47 ± 7.53 ng/ml. The mean plasma level of Vitamin D in those with uterine fibroids was significantly lower than in those without uterine fibroid (10.16 ± 7.78 vs. 14.35 ± 6.8; t = 2.517, P = 0.014). It also shows that 1 unit increase in Vitamin D level will reduce the risk of developing uterine fibroids by 8% (odds ratio = 0.92, 95% confidence interval = 0.86-0.99). Conclusion The predictors of uterine fibroids were fewer hours spent outdoors, middle social class and low Vitamin D levels. |
| Databáze: | OpenAIRE |
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