Evolution of the urinary proteome during human renal development and maturation: variations with gestational and postnatal age
| Autor: | Jennifer R. Charlton, Susan C. Kiley, Robert L. Chevalier, Matthew J. Gurka, Victoria F. Norwood |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Proteome Urinary system Antigens Differentiation Myelomonocytic Physiology Gestational Age Biology Kidney urologic and male genital diseases Statistics Nonparametric Antigens CD Lectins Internal medicine medicine Humans Chemokine CCL2 Age Factors Infant Newborn Gene Expression Regulation Developmental Infant Insulin-Like Growth Factor Binding Protein 1 Insulin-Like Growth Factor Binding Protein 2 Proteinuria Postnatal age Endocrinology Pediatrics Perinatology and Child Health Gestation Female Insulin-Like Growth Factor Binding Protein 6 Infant Premature |
| Zdroj: | Pediatric Research. 72:179-185 |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | Low birth weight is associated with deficits in nephron number in the infant kidney and increased risk of adulthood hypertension and renal dysfunction. Urinary biomarkers may be potential indicators of renal reserve, but little is known about the influence of gestational and postnatal age on the expression of urinary proteins. The aims of this study were to determine the relationships between selected urinary proteins and renal maturation. We hypothesized that urinary protein patterns would change over time during late nephrogenesis and renal maturation.Urine samples were collected at birth and over 12 mo from preterm (33-35 wk) and term (38-40 wk) infants. Candidate urinary proteins were identified by antibody array and quantified with enzyme-linked immunosorbent assay.Preterm infants at birth were found to have relatively elevated levels of insulin-like growth factor binding protein-1, -2, and -6, monocyte chemotactic protein-1, CD14, and sialic acid-binding Ig-like lectin 5. These markers gradually decline to levels similar to those of full-term infants by 2-6 mo of life. In contrast, many urinary markers in healthy full-term infants remain stable over the first year of life.Gestational and postnatal age must be considered when evaluating the utility of urinary biomarkers. |
| Databáze: | OpenAIRE |
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