V2 from a curtovirus is a suppressor of post-transcriptional gene silencing
| Autor: | Eduardo R. Bejarano, Liping Wang, Gabriel Morilla, Rosa Lozano-Durán, Araceli G. Castillo, Ana P. Luna, Edgar A. Rodríguez-Negrete |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Arabidopsis Viral Proteins 03 medical and health sciences chemistry.chemical_compound Virology RNA polymerase Curtovirus Gene silencing Geminiviridae Plant Diseases Genetics biology Arabidopsis Proteins fungi Begomovirus Plants Genetically Modified RNA-Dependent RNA Polymerase biology.organism_classification RNA silencing 030104 developmental biology chemistry Beet curly top virus RNA Interference DNA |
| Zdroj: | Journal of General Virology. 98:2607-2614 |
| ISSN: | 1465-2099 0022-1317 |
| DOI: | 10.1099/jgv.0.000933 |
| Popis: | The suppression of gene silencing is a key mechanism for the success of viral infection in plants. DNA viruses from the Geminiviridae family encode several proteins that suppress transcriptional and post-transcriptional gene silencing (TGS/PTGS). In Begomovirus, the most abundant genus of this family, three out of six genome-encoded proteins, namely C2, C4 and V2, have been shown to suppress PTGS, with V2 being the strongest PTGS suppressor in transient assays. Beet curly top virus (BCTV), the model species for the Curtovirus genus, is able to infect the widest range of plants among geminiviruses. In this genus, only one protein, C2/L2, has been described as inhibiting PTGS. We show here that, despite the lack of sequence homology with its begomoviral counterpart, BCTV V2 acts as a potent PTGS suppressor, possibly by impairing the RDR6 (RNA-dependent RNA polymerase 6)/suppressor of gene silencing 3 (SGS3) pathway. |
| Databáze: | OpenAIRE |
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