Iridoid compounds from the aerial parts of Swertia mussotii Franch. with cytotoxic activity
| Autor: | Huiming Huang, Haixia Wang, Xinmin Liu, Ning Jiang, Jingwei Lv, Yujiao Li, Hong-Ping Zhao |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Gentianaceae
Traditional medicine biology Iridoid 010405 organic chemistry medicine.drug_class Chemistry Organic Chemistry Plant Science biology.organism_classification 01 natural sciences Biochemistry Swertia 0104 chemical sciences Analytical Chemistry Human tumor 010404 medicinal & biomolecular chemistry Swertia mussotii Ic50 values medicine Cytotoxic T cell |
| Zdroj: | Natural Product Research. 35:1544-1549 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2019.1660332 |
| Popis: | One new secoiridoid compound swertiamarin B (1), along with a known compound lytanthosalin (2), were isolated from ethanol extract of the aerial parts of Swertia mussotii. Their structures were elucidated by the detailed analysis of comprehensive spectroscopic data. All compounds were first isolated from the Swertia genus. Their antitumor activities were evaluated for four human tumor cell lines (HCT-116, HepG2, MGC-803 and A549). Compounds 1 and 2 showed excellent cytotoxic activities toward the MGC-803 cell lines with IC50 values 3.61 and 12.04 μM, respectively. |
| Databáze: | OpenAIRE |
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