Anti-citrullinated protein antibody response after primary EBV infection in kidney transplant patients
| Autor: | Ineke J. M. ten Berge, Marieke L. Nijland, Dominique Baeten, Kristine Germar, Lianne Kraal, Cynthia M. Fehres |
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| Přispěvatelé: | Amsterdam institute for Infection and Immunity, Graduate School, AII - Infectious diseases, Clinical Immunology and Rheumatology, Nephrology, 01 Internal and external specialisms |
| Rok vydání: | 2018 |
| Předmět: |
Male
Epstein-Barr Virus Infections Herpesvirus 4 Human B Cells Physiology lcsh:Medicine Antibody Response medicine.disease_cause Biochemistry Anti-Citrullinated Protein Antibodies White Blood Cells 0302 clinical medicine Animal Cells Immune Physiology Medicine and Health Sciences Renal Transplantation Enzyme-Linked Immunoassays lcsh:Science skin and connective tissue diseases Immune Response Pathology and laboratory medicine education.field_of_study Immune System Proteins Multidisciplinary biology Drugs Anti–citrullinated protein antibody Medical microbiology Middle Aged Immunosuppressives Pathophysiology 3. Good health Rheumatoid arthritis Viruses Female Pathogens Cellular Types Antibody Research Article Adult musculoskeletal diseases Herpesviruses Immune Cells Immunology Population Surgical and Invasive Medical Procedures Rheumatoid Arthritis Research and Analysis Methods Microbiology Urinary System Procedures Antibodies Virus Autoimmune Diseases Nephropathy 03 medical and health sciences Rheumatology medicine Epstein-Barr virus Humans Immunoassays Antibody-Producing Cells education Aged Pharmacology 030203 arthritis & rheumatology Transplantation Blood Cells Biology and life sciences business.industry Arthritis lcsh:R Organisms Viral pathogens Proteins Glomerulonephritis IGA Organ Transplantation Cell Biology medicine.disease Kidney Transplantation Epstein–Barr virus Microbial pathogens Immunologic Techniques biology.protein lcsh:Q Clinical Immunology Clinical Medicine DNA viruses business 030215 immunology |
| Zdroj: | PLoS ONE PLOS ONE PLoS ONE, Vol 13, Iss 5, p e0197219 (2018) PLoS ONE, 13(5):e0197219. Public Library of Science |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0197219 |
| Popis: | Rheumatoid arthritis (RA) is a chronic inflammatory disease of synovial joints, characterized by the presence of the highly disease-specific anti-citrullinated protein antibodies (ACPA) in approximately 70% of patients. Epstein-Barr virus (EBV) has previously been suggested to be involved in the pathophysiology of RA. However, given the high incidence of EBV in the general population and the difficulty of detecting initial infection, providing a direct link between EBV infection and RA development has remained elusive. We hypothesized that primary EBV infection may be a trigger for the development of the ACPA response in vivo. Using a unique cohort of 26 kidney transplant patients with a primary EBV infection, the presence of ACPA before and following infection was determined. No increase in IgG anti-CCP2 titers was detected following EBV infection. IgG anti-CCP2 antibodies were present in two patients and borderline positive in another. These three patients were HLA-DR4 negative. To test whether EBV infection may trigger a non-class switched anti-CCP2 response, IgM anti-CCP2 antibodies were analyzed. No general trend in the IgM anti-CCP2 response was observed following EBV infection. Since two out of the three IgG anti-CCP2 (borderline) positive patients were diagnosed with IgA nephropathy, 23 additional IgA nephropathy patients were tested for IgG anti-CCP2, regardless of their EBV status. All of these patients were IgG anti-CCP2 negative, indicating that IgG anti-CCP2 is not commonly present in IgA nephropathy patients. Collectively, these data do not support the hypothesis that EBV does trigger the highly RA specific ACPA response. |
| Databáze: | OpenAIRE |
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