The association of genetic variants in chemokine genes with the risk of psoriasis vulgaris in Chinese population: A case-control study
| Autor: | Qiuhe Song, Xiaogang Xiong, Fei Hao, Kun Zhu, Jun Lu, Jin Zhang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male China Adolescent Receptors CCR5 psoriasis vulgaris Receptors CCR2 Observational Study 03 medical and health sciences Young Adult 0302 clinical medicine Asian People Polymorphism (computer science) Genotype Medicine Humans Psoriasis Genetic Predisposition to Disease Allele Genotyping Allele frequency Chemokine CCL2 Aged Polymorphism Genetic business.industry Case-control study General Medicine Odds ratio Middle Aged 030104 developmental biology 030220 oncology & carcinogenesis Relative risk Case-Control Studies Immunology MCP1 CCR2 Female business polymorphisms CCR5 Research Article chemokine genes |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | This study aimed to investigate the influence of polymorphisms in chemokine genes, including MCP1, CCR2, and CCR5 with psoriasis vulgaris (PV) risk in a Chinese population. The genotyping of studied polymorphisms through polymerase chain reaction (PCR) and sequencing was conducted in 142 PV patients and 147 healthy controls. The genotype distribution of the polymorphisms in the control group was checked to determine whether it conformed to Hardy–Weinberg equilibrium (HWE). The genotype and allele frequencies were compared between PV patients and the healthy controls using Chi-square test. Odds ratio (OR) with 95% confidence interval (95% CI) was calculated to assess the relative risk of PV related to genetic variants. CCR2 rs1799864 polymorphism was associated with significantly elevated risk of PV (AA+AG vs GG: OR = 1.62, 95% CI = 1.02–2.59; A vs G: OR = 1.48, 95% CI = 1.02–2.16). In the meanwhile, CCR5 rs1800024 polymorphism also exhibited significant differences in genotype and allele distribution (P |
| Databáze: | OpenAIRE |
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