Effects of a 1,2,4-triazole derivative liposome emulsion on the innate and adaptive immunity of puppies vaccinated against canine parvovirus and canine distemper
| Autor: | I. V. Kichun, M. M. Broshkov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Liposome
lcsh:Veterinary medicine General Veterinary biology Canine distemper animal diseases Canine parvovirus biology.organism_classification Acquired immune system medicine.disease vaccination Virology Vaccination absolute lymphocyte count Immune system Immunity biology.protein medicine neutrophil phagocytosis puppies lcsh:SF600-1100 Antibody specific IgG antibodies titre |
| Zdroj: | Bulgarian Journal of Veterinary Medicine, Vol 22, Iss 3, Pp 297-304 (2019) |
| ISSN: | 1313-3543 1311-1477 |
| Popis: | The aim of the study was the evaluate the immunomodulating effect of a 1,2,4-triazole derivative liposome emulsion (Trifuzol) in puppies vaccinated against parvovirus enteritis and canine distemper. The used Trifuzol liposome emulsion led to a significant increase in the absolute number of lympho-cytes and their immunoregulatory subpopulations, phagocytic activity of neutrophils. The level of antibodies against parvovirus enteritis (CPV) and canine distemper (CDV) in vaccinated and Trifuzol-treated puppies reached zero values which were statistically significantly lower than those in vac-cinated-only puppies (21.0 U/mL and 27.0 U/mL, respectively). It was concluded that the tested liposome emulsion of Trifuzol had an positive effect on the humoral immunity in puppies and can be used in clinical practice as an immunomodulatory agent. |
| Databáze: | OpenAIRE |
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