Successful treatment with yttrium-90 microspheres in a metastatic breast cancer patient and sclerosing cholangitis
| Autor: | Cedric Van Marcke, Philippe D'Abadie, Emmanuel Seront, Aurélie Louvet |
|---|---|
| Přispěvatelé: | UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie, UCL - (SLuc) Service de médecine nucléaire, UCL - (SLuc) Unité d'oncologie médicale, UCL - (SLuc) Centre de malformations vasculaires congénitales |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
Curative intent medicine.medical_specialty business.industry Case Report trans-arterial radioembolization Malignancy medicine.disease Metastatic breast cancer 030218 nuclear medicine & medical imaging 03 medical and health sciences breast cancer 0302 clinical medicine Breast cancer 030220 oncology & carcinogenesis Internal medicine Localized disease Yttrium-90 microspheres yttrium-90 medicine business liver metastases metastasis-directed therapies Biotechnology |
| Zdroj: | Future Science OA Future science OA, Vol. 7, no.7, p. FSO716 (2021) |
| ISSN: | 2056-5623 |
| Popis: | Breast cancer is the most common malignancy occurring in women worldwide. More than 90% of patients present with localized disease are treated with curative intent; however, recurrence can occur with development of metastatic lesions. Frequently associated with extra-hepatic lesions, localized treatments (surgery or stereotaxic body radiotherapy) are rarely proposed in liver lesions. 90Y radioembolization has extensively been evaluated in colorectal cancer, but its role in breast cancer with isolated liver metastases remains largely unknown. Pre-existing liver diseases are known risk factors for 90Y induced liver toxicity. Not considered as an excluding factor for this treatment, data are limited regarding its safe use with cholangitis. We report a successful control of liver metastases by 90Y radioembolization in a breast cancer patient. Lay abstract Breast cancer is the most common malignancy occurring in women worldwide. Metastasis-directed therapies are more and more often offered to patients in order to delay systemic treatments; however, their role in improving survival remains unknown. Trans-arterial radioembolization with 90Y appears to be an interesting strategy in breast cancer with isolated liver metastases, even if its survival benefit remains largely unknown. Safety of trans-arterial radioembolization also remains under investigated in patients with previous liver disease. We report a successful control of liver metastases by 90Y radioembolization in a breast cancer patient. |
| Databáze: | OpenAIRE |
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