Optimizing quantification of MK6240 tau PET in unimpaired older adults

Autor: Theresa M. Harrison, Tyler J. Ward, Alice Murphy, Suzanne L. Baker, Pablo A. Dominguez, Robert Koeppe, Prashanthi Vemuri, Samuel N. Lockhart, Youngkyoo Jung, Danielle J. Harvey, Laura Lovato, Arthur W. Toga, Joseph Masdeu, Hwamee Oh, Darren R. Gitelman, Neelum Aggarwal, Heather M. Snyder, Laura D. Baker, Charles DeCarli, William J. Jagust, Susan M. Landau
Rok vydání: 2022
Předmět:
Zdroj: NeuroImage. 265
ISSN: 1095-9572
Popis: Accurate measurement of Alzheimer's disease (AD) pathology in older adults without significant clinical impairment is critical to assessing intervention strategies aimed at slowing AD-related cognitive decline. The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (POINTER) is a 2-year randomized controlled trial to evaluate the effect of multicomponent risk reduction strategies in older adults (60-79 years) who are cognitively unimpaired but at increased risk for cognitive decline/dementia due to factors such as cardiovascular disease and family history. The POINTER Imaging ancillary study is collecting tau-PET ([
Databáze: OpenAIRE