Marine natural products and their potential applications as anti-infective agents
| Autor: | Mark T. Hamann, Marwa S. Donia |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Cancer chemotherapy
Antifungal Agents Antiprotozoal Agents Antitubercular Agents Marine Biology Drug resistance Biology 01 natural sciences Antiviral Agents Natural (archaeology) Article Microbiology 03 medical and health sciences Marine bacteriophage Animals Humans 14. Life underwater 030304 developmental biology Anthelmintics 0303 health sciences Kahalalide F 010405 organic chemistry Ecology Drugs Investigational Invertebrates 0104 chemical sciences Anti-Bacterial Agents Infectious Diseases Anti-Infective Agents Phytotherapy |
| Zdroj: | The Lancet. Infectious Diseases |
| ISSN: | 1473-3099 |
| Popis: | Summary The oceans are a unique resource that provide a diverse array of natural products, primarily from invertebrates such as sponges, tunicates, bryozoans, and molluscs, and from marine bacteria and cyanobacteria. As infectious diseases evolve and develop resistance to existing pharmaceuticals, the marine environment provides novel leads against fungal, parasitic, bacterial, and viral diseases. Many marine natural products have successfully advanced to the late stages of clinical trials, including dolastatin 10, ecteinascidin-743, kahalalide F, and aplidine, and a growing number of candidates have been selected as promising leads for extended preclinical assessment. Although many marine-product clinical trials are for cancer chemotherapy, drug resistance, emerging infectious diseases, and the threat of bioterrorism have all contributed to the interest in assessing natural ocean products in the treatment of infectious organisms. In this review, we focus on the pharmacologically tested marine leads that have shown in-vivo efficacy or potent in-vitro activity against infectious and parasitic diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|