Pulmonary microsporidiosis due to Encephalitozoon hellem in a patient with AIDS
| Autor: | S. Corona, Norman J. Pieniazek, Govinda S. Visvesvara, Massimo Scaglia, Susan B. Slemenda, G. P. Croppo, A. Orani, A J da Silva, Luciano Sacchi, Simonetta Gatti, A. M. Bernuzzi, S Wallace |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Microbiology (medical) Pathology medicine.medical_specialty Lung Diseases Parasitic Immunoblotting Molecular Sequence Data Biology Microsporidiosis Polymerase Chain Reaction Cell Line Albendazole Fatal Outcome parasitic diseases medicine Animals Humans Lung AIDS-Related Opportunistic Infections medicine.diagnostic_test fungi Respiratory disease Encephalitozoon medicine.disease biology.organism_classification Encephalitozoonosis Radiography Infectious Diseases medicine.anatomical_structure Bronchoalveolar lavage RNA Ribosomal Microsporidia Bronchoalveolar Lavage Fluid RNA Protozoan medicine.drug |
| Zdroj: | Journal of Infection. 34:119-126 |
| ISSN: | 0163-4453 |
| DOI: | 10.1016/s0163-4453(97)92414-2 |
| Popis: | The microsporidian Encephalitozoon hellem is being reported with increasing frequency in HIV-positive subjects, as an agent of disseminated microsporidiosis without involving the gastrointestinal tract. We describe a case of pulmonary microsporidiosis in a 27-year-old Italian man with AIDS who developed fever, cough, and dyspnea. A chest X-ray showed multiple bilateral pulmonary opacities and mediastinal lymph-node enlargement. Stained smears of bronchoalveolar lavage sediment showed oval structures consistent with microsporidian spores. Viral, bacterial and fungal cultures were repeatedly negative, whereas microsporidia were successfully cultured in human and bovine fibroblast cell lines. Analysis of electron micrographs indicated that the isolate belonged to the genus Encephalitozoon. Based on further immunological, biochemical and molecular studies it was characterized as E. hellem. Even though a temporary improvement with albendazole therapy was noticed, the patient deteriorated clinically and died of severe respiratory distress. |
| Databáze: | OpenAIRE |
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