Chronic consumption of short-chain fructooligosaccharides by healthy subjects decreased basal hepatic glucose production but had no effect on insulin-stimulated glucose metabolism
| Autor: | F. Bornet, F. Guyon, C. Alamowitch, J.-L. Barry, Gérard Slama, A. Blayo, Salwa W. Rizkalla, A. Laffitte, Jing Luo, A. Boussairi |
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| Přispěvatelé: | ProdInra, Migration, Laboratoire de technologie appliquée à la nutrition, Institut National de la Recherche Agronomique (INRA) |
| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Erythrocytes 030309 nutrition & dietetics Glucose uptake medicine.medical_treatment Medicine (miscellaneous) Blood lipids Oligosaccharides 030209 endocrinology & metabolism Carbohydrate metabolism Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Double-Blind Method Internal medicine medicine Dietary Carbohydrates Humans Insulin Triglycerides ComputingMilieux_MISCELLANEOUS Apolipoproteins B 0303 health sciences Nutrition and Dietetics Cross-Over Studies Apolipoprotein A-I Dose-Response Relationship Drug Body Weight Cholesterol HDL Fructose Metabolism Glucose clamp technique Fatty Acids Volatile Lipids Lactulose [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition Endocrinology Glucose chemistry Basal (medicine) Liver Fermentation Glucose Clamp Technique [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition |
| Zdroj: | American Journal of Clinical Nutrition American Journal of Clinical Nutrition, American Society for Nutrition, 1996, 63 (6), pp.939-945 |
| ISSN: | 0002-9165 |
| Popis: | We aimed to study the effects of chronic ingestion of short-chain fructooligosaccharides (FOS), an indigestible carbohydrate, on hepatic glucose production, insulin-mediated glucose metabolism, erythrocyte insulin binding, and blood lipids in healthy subjects. Twelve healthy volunteers received either 20 g FOS/d or sucrose for 4 wk in a double-blind crossover design. FOS did not modify fasting plasma glucose and insulin concentrations. Mean (+/- SEM) basal hepatic glucose production was lower after FOS than after sucrose consumption (2.18 +/- 0.10 compared with 2.32 +/- 0.09 mg.kg-1, min-1, respectively; P < 0.02, paired Student's t test). However, neither insulin suppression of hepatic glucose production nor insulin stimulation of glucose uptake measured by hyperinsulinemic clamp was significantly different between the two dietary periods. Erythrocyte insulin binding was also comparable. Serum triacylglycerols, total and high-density- lipoprotein cholesterol, apolipoproteins A-I and B, and lipoprotein(a) were not modified by FOS. To try to understand why FOS did not increase serum lipids, the in vitro production of short-chain fatty acids from FOS was evaluated by using human fecal inoculum and compared with that from lactulose, which was found to increase serum lipids. FOS produced an acetate-propionate ratio two times lower than that of lactulose. We conclude that 4 wk of 20 g FOS/d decreased basal hepatic glucose production but had no detectable effect on insulin-stimulated glucose metabolism in healthy subjects. The colonic fermentation pattern of undigestible carbohydrates may be relevant to predicting their metabolic effects. |
| Databáze: | OpenAIRE |
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